|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM295466715 |
| 003 |
DE-627 |
| 005 |
20250225033104.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2019 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1111/vcp.12689
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0984.xml
|
| 035 |
|
|
|a (DE-627)NLM295466715
|
| 035 |
|
|
|a (NLM)30924545
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a van Rooyen, Liesl J
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Thromboelastographic platelet mapping in dogs with complicated Babesia rossi infection
|
| 264 |
|
1 |
|c 2019
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 11.04.2019
|
| 500 |
|
|
|a Date Revised 11.04.2019
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2018 American Society for Veterinary Clinical Pathology.
|
| 520 |
|
|
|a BACKGROUND: Dogs with Babesia rossi infection display a normocoagulable thromboelastogram, despite being markedly thrombocytopenic, which is purportedly due to large-scale platelet activation. Thromboelastographic platelet mapping (TEG-PM) evaluates individual contributions of thrombin, fibrinogen, and platelets to clot formation, and may elucidate some of the pathomechanisms of thrombocytopenia-associated hemostatic alterations
|
| 520 |
|
|
|a OBJECTIVE: This study investigated potential differences in TEG-PM variables in dogs with complicated B rossi infection compared with healthy controls, and whether these variables correlated with platelet activation indices
|
| 520 |
|
|
|a METHODS: The maximum amplitude (MA) following thrombin generation (MAThrombin ) was determined using kaolin-activated TEG. The TEG-PM variables included MA following the addition of platelet agonists arachidonic acid (MAAA ) and adenosine diphosphate (MAADP ), and MA due to fibrin alone (MAFibrin ). In addition, platelet indices and fibrinogen concentrations were determined
|
| 520 |
|
|
|a RESULTS: Thirteen dogs with complicated B rossi infection and five healthy controls were included. The median MAFibrin and fibrinogen concentrations were significantly higher (P < 0.01 for both) and median platelet count was significantly lower (P < 0.01) in the babesiosis group vs the control group. No significant differences were found for MAThrombin and MAAA/ADP . maximum amplitude due to fibrin alone was positively correlated with fibrinogen concentration (r = 0.735), mean platelet volume (r = 0.517), and mean platelet mass (r = 0.498), and negatively correlated with hematocrit (r = -0.685), platelet count (r = -0.476), and plateletcrit (r = -0.479) (P < 0.05 for all)
|
| 520 |
|
|
|a CONCLUSIONS: This study suggests that the presence of hyperfibrinogenemia offsets the severe thrombocytopenia associated with B rossi to result in normal thromboelastograms and lack of overt clinical bleeding
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a MAFibrin
|
| 650 |
|
4 |
|a dogs
|
| 650 |
|
4 |
|a hyperfibrinogenemia
|
| 650 |
|
4 |
|a thrombocytopenia
|
| 650 |
|
7 |
|a Arachidonic Acid
|2 NLM
|
| 650 |
|
7 |
|a 27YG812J1I
|2 NLM
|
| 650 |
|
7 |
|a Fibrinogen
|2 NLM
|
| 650 |
|
7 |
|a 9001-32-5
|2 NLM
|
| 650 |
|
7 |
|a Apyrase
|2 NLM
|
| 650 |
|
7 |
|a EC 3.6.1.5
|2 NLM
|
| 700 |
1 |
|
|a Hooijberg, Emma H
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Schoeman, Johan P
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Goddard, Amelia
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 48(2019), 1 vom: 29. März, Seite 11-18
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
|
| 773 |
1 |
8 |
|g volume:48
|g year:2019
|g number:1
|g day:29
|g month:03
|g pages:11-18
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1111/vcp.12689
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 48
|j 2019
|e 1
|b 29
|c 03
|h 11-18
|