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20231225083719.0 |
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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201901179
|2 doi
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|a pubmed24n0984.xml
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|a (DE-627)NLM295463643
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|a (NLM)30924234
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhang, Chi
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Artificial Super Neutrophils for Inflammation Targeting and HClO Generation against Tumors and Infections
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1 |
|c 2019
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 27.11.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Neutrophils are powerful effector leukocytes that play an important role in innate immune systems for opposing tumor progression and ameliorating pathogen infections. Inspired by their distinct functions against tumors and infections, the artificial "super neutrophils" are proposed with excellent inflammation targeting and hypochlorous acid (HClO) generation characteristics for targeting and eliminating malignant tumor cells and pathogens. The "super neutrophils" are fabricated by embedding glucose oxidase (GOx) and chloroperoxidase (CPO) into zeolitic imidazolate framework-8 (ZIF-8) for HClO generation via enzymatic cascades, and then encapsulating them with the neutrophil membrane (NM) for inflammation targeting. In vitro and in vivo results indicate that these artificial "super neutrophils" can generate seven times higher reactive HClO than the natural neutrophils for eradicating tumors and infections. The "super neutrophils" demonstrated here with easy fabrication and good neutrophil-mimicking property exhibit great potential for biomedical applications
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|a Journal Article
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|a HClO
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|a antibiosis
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|a antitumor
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|a biomimetic materials
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|a neutrophils
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|a Anti-Inflammatory Agents
|2 NLM
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| 650 |
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|a Antineoplastic Agents
|2 NLM
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| 650 |
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|a Enzymes, Immobilized
|2 NLM
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| 650 |
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|a Membranes, Artificial
|2 NLM
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| 650 |
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|a Zeolites
|2 NLM
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| 650 |
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|a 1318-02-1
|2 NLM
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| 650 |
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|a Hypochlorous Acid
|2 NLM
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| 650 |
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|a 712K4CDC10
|2 NLM
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| 650 |
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|a Glucose Oxidase
|2 NLM
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| 650 |
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|a EC 1.1.3.4
|2 NLM
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| 650 |
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|a Chloride Peroxidase
|2 NLM
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| 650 |
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|a EC 1.11.1.10
|2 NLM
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| 700 |
1 |
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|a Zhang, Lu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Fan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Run-Qing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Wen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhuang, Ze-Nan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Chuan-Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xian-Zheng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 19 vom: 20. Mai, Seite e1901179
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:31
|g year:2019
|g number:19
|g day:20
|g month:05
|g pages:e1901179
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201901179
|3 Volltext
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|d 31
|j 2019
|e 19
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|h e1901179
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