Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype Insights from an analysis of 500 cases

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype : Insights from an analysis of 500 cases

Copyright © 2019 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 203(2019) vom: 20. Juni, Seite 1-8
1. Verfasser: Watad, Abdulla (VerfasserIn)
Weitere Verfasser: Bragazzi, Nicola Luigi, McGonagle, Dennis, Adawi, Mohammed, Bridgewood, Charlie, Damiani, Giovanni, Alijotas-Reig, Jaume, Esteve-Valverde, Enrique, Quaresma, Mariana, Amital, Howard, Shoenfeld, Yehuda
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't ASIA syndrome Foreign material International syndrome registry Silicone breast implants Vaccines Adjuvants, Immunologic Hepatitis B Vaccines Influenza Vaccines
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100 1 |a Watad, Abdulla  |e verfasserin  |4 aut 
245 1 0 |a Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype  |b Insights from an analysis of 500 cases 
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500 |a Date Revised 29.01.2021 
500 |a published: Print-Electronic 
500 |a CommentIn: Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):11-13. doi: 10.26355/eurrev_202101_24337. - PMID 33506886 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2019 Elsevier Inc. All rights reserved. 
520 |a BACKGROUND: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry 
520 |a METHODS: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed 
520 |a RESULTS: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001) 
520 |a CONCLUSIONS: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a ASIA syndrome 
650 4 |a Foreign material 
650 4 |a International syndrome registry 
650 4 |a Silicone breast implants 
650 4 |a Vaccines 
650 7 |a Adjuvants, Immunologic  |2 NLM 
650 7 |a Hepatitis B Vaccines  |2 NLM 
650 7 |a Influenza Vaccines  |2 NLM 
700 1 |a Bragazzi, Nicola Luigi  |e verfasserin  |4 aut 
700 1 |a McGonagle, Dennis  |e verfasserin  |4 aut 
700 1 |a Adawi, Mohammed  |e verfasserin  |4 aut 
700 1 |a Bridgewood, Charlie  |e verfasserin  |4 aut 
700 1 |a Damiani, Giovanni  |e verfasserin  |4 aut 
700 1 |a Alijotas-Reig, Jaume  |e verfasserin  |4 aut 
700 1 |a Esteve-Valverde, Enrique  |e verfasserin  |4 aut 
700 1 |a Quaresma, Mariana  |e verfasserin  |4 aut 
700 1 |a Amital, Howard  |e verfasserin  |4 aut 
700 1 |a Shoenfeld, Yehuda  |e verfasserin  |4 aut 
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