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01000naa a22002652 4500 |
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NLM295366028 |
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DE-627 |
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20231225083514.0 |
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cr uuu---uuuuu |
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231225s2019 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2019.03.005
|2 doi
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2 |
|a pubmed24n0984.xml
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|a (DE-627)NLM295366028
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|a (NLM)30914281
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|a (PII)S1521-6616(18)30557-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Jia, Zheng-Hu
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Activated γδ T cells exhibit cytotoxicity and the capacity for viral clearance in patients with acute hepatitis B
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| 264 |
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1 |
|c 2019
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 13.02.2020
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| 500 |
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|a Date Revised 13.02.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2019 Elsevier Inc. All rights reserved.
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|a γδ T cells are a unique population of lymphocytes that have regulatory roles in patients with chronic hepatitis B (CHB); however, their role in acute hepatitis B (AHB) infection remains unclear. Phenotype and function of γδ T cells were analyzed in 29 AHB patients, 28 CHB patients, and 30 healthy controls (HCs) using immunofunctional assays. Compared with HCs and CHB patients, decreased peripheral and increased hepatic γδ T cells were found in AHB patients. Increased hepatic γδ T cells in AHB patients were attributed to elevated hepatic chemokine levels. Peripheral γδ T cells exhibited highly activated and terminally differentiated memory phenotype in AHB patients. Consistently, peripheral γδ T cells in AHB patients showed increased cytotoxic capacity and enhanced antiviral activity which was further proved in longitudinal study. Activated γδ T cells in AHB patients exhibited increased cytotoxicity and capacity for viral clearance associated with liver injury and the control of infection
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| 650 |
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4 |
|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Antiviral activity
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| 650 |
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4 |
|a Cytokine
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| 650 |
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4 |
|a Cytotoxity
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| 650 |
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4 |
|a Longitudinal study
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| 650 |
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4 |
|a γδ T cells
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| 650 |
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7 |
|a Chemokines
|2 NLM
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| 650 |
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7 |
|a DNA, Viral
|2 NLM
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| 700 |
1 |
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|a Li, Yuan-Yuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Jing-Ya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Ji-Yuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Ang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guo, Xiao-Dong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Zhen-Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Fu-Sheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Xiao-Li
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 202(2019) vom: 01. Mai, Seite 40-48
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:202
|g year:2019
|g day:01
|g month:05
|g pages:40-48
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2019.03.005
|3 Volltext
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|d 202
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|h 40-48
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