|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM295337214 |
| 003 |
DE-627 |
| 005 |
20231225083437.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2019 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1155/2019/7920540
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0984.xml
|
| 035 |
|
|
|a (DE-627)NLM295337214
|
| 035 |
|
|
|a (NLM)30911292
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Li, Jingjing
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats
|
| 264 |
|
1 |
|c 2019
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 13.05.2019
|
| 500 |
|
|
|a Date Revised 09.03.2020
|
| 500 |
|
|
|a published: Electronic-eCollection
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a We investigated the effects of aerobic exercise on the expression of hippocampal synaptic plasticity-associated proteins in rats with type 2 diabetes and their possible mechanisms. A type 2 diabetes rat model was established with 8 weeks of high-fat diet combined with a single intraperitoneal injection of streptozotocin (STZ). Then, a 4-week aerobic exercise intervention was conducted. Memory performance was measured with Y maze tests. The expression and activity of synaptic plasticity-associated proteins and of proteins involved in the PI3K/Akt/mTOR, AMPK/Sirt1, and NFκB/NLRP3/IL-1β signaling pathways were evaluated by western blot. Our results show that aerobic exercise promotes the expression of synaptic plasticity-associated proteins in the hippocampus of diabetic rats. Aerobic exercise also activates the PI3K/Akt/mTOR and AMPK/Sirt1 signaling pathways and inhibits the NFκB/NLRP3/IL-1β signaling pathway in the hippocampus of diabetic rats. Therefore, modulating the PI3K/Akt/mTOR, AMPK/Sirt1, and NFκB/NLRP3/IL-1β signaling pathways is probably the mechanism of aerobic exercise upregulating the expression of hippocampal synaptic plasticity-associated proteins in diabetic rats
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 700 |
1 |
|
|a Liu, Yuran
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Beibei
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Feng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hu, Jingyun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Qian
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Mingming
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lou, Shujie
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Neural plasticity
|d 1998
|g 2019(2019) vom: 25., Seite 7920540
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnns
|
| 773 |
1 |
8 |
|g volume:2019
|g year:2019
|g day:25
|g pages:7920540
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1155/2019/7920540
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_21
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 2019
|j 2019
|b 25
|h 7920540
|