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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201808021
|2 doi
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|a pubmed24n0984.xml
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|a (DE-627)NLM29531253X
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|a (NLM)30908801
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Zhou, Cheng
|e verfasserin
|4 aut
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|a A Chain-Elongated Oligophenylenevinylene Electrolyte Increases Microbial Membrane Stability
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 29.08.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a A novel conjugated oligoelectrolyte (COE) material, named S6, is designed to have a lipid-bilayer stabilizing topology afforded by an extended oligophenylenevinylene backbone. S6 intercalates biological membranes acting as a hydrophobic support for glycerophospholipid acyl chains. Indeed, Escherichia coli treated with S6 exhibits a twofold improvement in butanol tolerance, a relevant feature to achieve within the general context of modifying microorganisms used in biofuel production. Filamentous growth, a morphological stress response to butanol toxicity in E. coli, is observed in untreated cells after incubation with 0.9% butanol (v/v), but is mitigated by S6 treatment. Real-time fluorescence imaging using giant unilamellar vesicles reveals the extent to which S6 counters membrane instability. Moreover, S6 also reduces butanol-induced lipopolysaccharide release from the outer membrane to further maintain cell integrity. These findings highlight a deliberate effort in the molecular design of a chain-elongated COE to stabilize microbial membranes against environmental challenges
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|a Journal Article
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|a biofuels
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|a butanol tolerance
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|a conjugated oligoelectrolytes
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|a membrane integrity
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|a membrane stability
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|a Butanols
|2 NLM
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|a Electrolytes
|2 NLM
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|a Lipopolysaccharides
|2 NLM
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|a Vinyl Compounds
|2 NLM
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|a Chia, Geraldine W N
|e verfasserin
|4 aut
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|a Ho, James C S
|e verfasserin
|4 aut
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|a Moreland, Alex S
|e verfasserin
|4 aut
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|a Seviour, Thomas
|e verfasserin
|4 aut
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|a Liedberg, Bo
|e verfasserin
|4 aut
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| 700 |
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|a Parikh, Atul N
|e verfasserin
|4 aut
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|a Kjelleberg, Staffan
|e verfasserin
|4 aut
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|a Hinks, Jamie
|e verfasserin
|4 aut
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|a Bazan, Guillermo C
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 18 vom: 02. Mai, Seite e1808021
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:31
|g year:2019
|g number:18
|g day:02
|g month:05
|g pages:e1808021
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|u http://dx.doi.org/10.1002/adma.201808021
|3 Volltext
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