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20231225083113.0 |
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cr uuu---uuuuu |
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231225s2019 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1094/PDIS-08-18-1355-RE
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0983.xml
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|a (DE-627)NLM29518566X
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|a (NLM)30895869
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wang, Yong
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Antifungal Activity and Action Mechanism of the Natural Product Cinnamic Acid Against Sclerotinia sclerotiorum
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| 264 |
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|c 2019
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 10.07.2019
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|a Date Revised 24.02.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Sclerotinia stem rot caused by Sclerotinia sclerotiorum (Lib.) de Bary spreads worldwide and causes serious economic losses. Considering the development of fungicide resistance and chemical residues, it is urgently necessary to explore alternative fungicides. In this study, the activity of the natural product cinnamic acid was assessed. The EC50 values for cinnamic acid inhibition of mycelial growth of 103 S. sclerotiorum strains ranged from 9.37 to 42.54 µg/ml with an average EC50 value of 18.77 (±3.39) µg/ml. No cross-resistance was detected between cinnamic acid and the commonly used fungicides carbendazim or dimethachlon. After treatment with cinnamic acid, mycelia distorted with more branches, no sclerotia developed, and the oxalic acid content decreased, whereas cell membrane permeability increased significantly. In pot experiments, cinnamic acid at 2,000 µg/ml provided over 95% efficacy against both carbendazim-sensitive and carbendazim-resistant strains of S. sclerotiorum. The expression of the sclerotia development-correlated genes Sac1, Pac1, Smk1, and Pka1 decreased, whereas the Cna1 gene expression increased. Altogether, cinnamic acid shows potential to be a natural alternative to commercial fungicides or a lead compound to develop new fungicides for the control of Sclerotinia stem rot. The biological characteristics contribute to the understanding of the action mechanism of cinnamic acid against S. sclerotiorum
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| 650 |
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|a Journal Article
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7 |
|a Antifungal Agents
|2 NLM
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| 650 |
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7 |
|a Biological Products
|2 NLM
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| 650 |
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7 |
|a Cinnamates
|2 NLM
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| 650 |
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7 |
|a cinnamic acid
|2 NLM
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| 650 |
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7 |
|a 140-10-3
|2 NLM
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| 700 |
1 |
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|a Sun, Yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Jiali
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Mingxia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Miaomaio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Juntao
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Plant disease
|d 1997
|g 103(2019), 5 vom: 03. Mai, Seite 944-950
|w (DE-627)NLM098181742
|x 0191-2917
|7 nnns
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| 773 |
1 |
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|g volume:103
|g year:2019
|g number:5
|g day:03
|g month:05
|g pages:944-950
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| 856 |
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|u http://dx.doi.org/10.1094/PDIS-08-18-1355-RE
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