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231225s2019 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/adma.201806957
|2 doi
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|a pubmed25n0982.xml
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|a (NLM)30856290
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Ruan, Huitong
|e verfasserin
|4 aut
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| 245 |
1 |
2 |
|a A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 27.11.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Patients with advanced melanoma that is of low tumor-associated antigen (TAA) expression often respond poorly to PD-1/PD-L1 blockade therapy. Epigenetic modulators, such as hypomethylation agents (HMAs), can enhance the antitumor immune response by inducing TAA expression. Here, a dual bioresponsive gel depot that can respond to the acidic pH and reactive oxygen species (ROS) within the tumor microenvironment (TME) for codelivery of anti-PD1 antibody (aPD1) and Zebularine (Zeb), an HMA, is engineered. aPD1 is first loaded into pH-sensitive calcium carbonate nanoparticles (CaCO3 NPs), which are then encapsulated in the ROS-responsive hydrogel together with Zeb (Zeb-aPD1-NPs-Gel). It is demonstrated that this combination therapy increases the immunogenicity of cancer cells, and also plays roles in reversing immunosuppressive TME, which contributes to inhibiting the tumor growth and prolonging the survival time of B16F10-melanoma-bearing mice
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|a Journal Article
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4 |
|a bioresponsive materials
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| 650 |
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|a drug delivery
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| 650 |
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4 |
|a epigenetic modulation
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| 650 |
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4 |
|a immune checkpoint blockade
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| 650 |
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4 |
|a immunotherapy
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| 650 |
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|a Antibodies, Monoclonal
|2 NLM
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| 650 |
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|a Antibodies, Monoclonal, Humanized
|2 NLM
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| 650 |
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|a Antineoplastic Agents
|2 NLM
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| 650 |
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|a Immunosuppressive Agents
|2 NLM
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| 650 |
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|a Programmed Cell Death 1 Receptor
|2 NLM
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| 650 |
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|a Reactive Oxygen Species
|2 NLM
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| 650 |
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|a atezolizumab
|2 NLM
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| 650 |
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7 |
|a 52CMI0WC3Y
|2 NLM
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| 650 |
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|a Cytidine
|2 NLM
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| 650 |
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|a 5CSZ8459RP
|2 NLM
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| 650 |
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|a pyrimidin-2-one beta-ribofuranoside
|2 NLM
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| 650 |
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|a 7A9Y5SX0GY
|2 NLM
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| 650 |
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|a Calcium Carbonate
|2 NLM
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| 650 |
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|a H0G9379FGK
|2 NLM
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| 700 |
1 |
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|a Hu, Quanyin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wen, Di
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Guojun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Yifei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Jinqiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Hao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Weiyue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gu, Zhen
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 17 vom: 15. Apr., Seite e1806957
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
8 |
|g volume:31
|g year:2019
|g number:17
|g day:15
|g month:04
|g pages:e1806957
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201806957
|3 Volltext
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|d 31
|j 2019
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|h e1806957
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