Repository corticotropin injection reverses critical elements of the TLR9/B cell receptor activation response in human B cells in vitro

Copyright © 2019 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 201(2019) vom: 30. Apr., Seite 70-78
1. Verfasser: Olsen, Nancy J (VerfasserIn)
Weitere Verfasser: Benko, Ann L, McAloose, Carl A, Becker, Patrice M, Wright, Dale, Sunyer, Teresa, Kawasawa, Yuka Imamura, Kovacs, William J
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Adrenocorticotropin Antibodies B cell Gene regulation Human Toll like receptors RNA, Messenger mehr... Receptors, Antigen, B-Cell TLR9 protein, human Toll-Like Receptor 9 Adrenocorticotropic Hormone 9002-60-2
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100 1 |a Olsen, Nancy J  |e verfasserin  |4 aut 
245 1 0 |a Repository corticotropin injection reverses critical elements of the TLR9/B cell receptor activation response in human B cells in vitro 
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500 |a Citation Status MEDLINE 
520 |a Copyright © 2019 Elsevier Inc. All rights reserved. 
520 |a We sought evidence for direct effects of repository corticotropin (RCI; an FDA-approved treatment for selected cases of SLE) on isolated human B lymphocytes activated by engagement of TLR9 and B cell receptors. ODN 2395/αIgM treatment was found to result in induction of 162 distinct mRNAs and suppression of 80 mRNAs at 24 h. RCI treatment resulted in suppression of 14 of the ODN 2395/αIgM -induced mRNAs (mean suppression to 23.6 ± 3.1% of stimulated value). The RCI-suppressed mRNAs included two critical regulators of class switch recombination, AICDA and BATF. RCI treatment also resulted in induction of 5 of the ODN 2395/αIgM -suppressed mRNAs (mean induction by RCI = 7.65 ± 2.34-fold). The RCI-induced mRNAs included SLAMF3, a cell surface receptor capable of inhibiting autoantibody responses. These studies reveal that RCI treatment of human B cells reverses key elements of the early mRNA response to TLR9 and B cell receptor engagement 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
650 4 |a Adrenocorticotropin 
650 4 |a Antibodies 
650 4 |a B cell 
650 4 |a Gene regulation 
650 4 |a Human 
650 4 |a Toll like receptors 
650 7 |a RNA, Messenger  |2 NLM 
650 7 |a Receptors, Antigen, B-Cell  |2 NLM 
650 7 |a TLR9 protein, human  |2 NLM 
650 7 |a Toll-Like Receptor 9  |2 NLM 
650 7 |a Adrenocorticotropic Hormone  |2 NLM 
650 7 |a 9002-60-2  |2 NLM 
700 1 |a Benko, Ann L  |e verfasserin  |4 aut 
700 1 |a McAloose, Carl A  |e verfasserin  |4 aut 
700 1 |a Becker, Patrice M  |e verfasserin  |4 aut 
700 1 |a Wright, Dale  |e verfasserin  |4 aut 
700 1 |a Sunyer, Teresa  |e verfasserin  |4 aut 
700 1 |a Kawasawa, Yuka Imamura  |e verfasserin  |4 aut 
700 1 |a Kovacs, William J  |e verfasserin  |4 aut 
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773 1 8 |g volume:201  |g year:2019  |g day:30  |g month:04  |g pages:70-78 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2019.02.009  |3 Volltext 
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