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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.12972
|2 doi
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|a pubmed24n0981.xml
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|a (DE-627)NLM294356355
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|a (NLM)30811044
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Huang, Lixing
|e verfasserin
|4 aut
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| 245 |
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|a The role of rpoS in the regulation of Vibrio alginolyticus virulence and the response to diverse stresses
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|c 2019
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 10.05.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 John Wiley & Sons Ltd.
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|a Vibrio alginolyticus is a leading aquatic pathogen, causing huge losses to aquaculture. rpoS has been proven to play a variety of important roles in stress response and virulence in several bacteria. In our previous study, upon treatment with Cu2+ , Pb2+ , Hg2+ and low pH, the expression levels of rpoS were downregulated as assessed by RNA-seq, while impaired adhesion ability was observed, indicating that rpoS might play roles in the regulation of adhesion. In the present study, the RNAi technology was used to knockdown rpoS in V. alginolyticus. In comparison with wild-type V. alginolyticus, RNAi-treated bacteria showed significantly impaired abilities of adhesion, growth, haemolytic, biofilm production, movement and virulence. Meanwhile, alterations of temperature, salinity, pH and starvation starkly affected rpoS expression. The present data suggested that rpoS is a critical regulator of virulence in V. alginolyticus; in addition, rpoS regulates bacterial adhesion in response to temperature, pH and nutrient content changes. These are helpful to explore its pathogenic mechanism and provide reference for disease control
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|a Journal Article
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|a Vibrio alginolyticus
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| 650 |
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4 |
|a rpoS
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|a adhesion
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| 650 |
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4 |
|a virulence
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|a Bacterial Proteins
|2 NLM
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| 650 |
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|a Sigma Factor
|2 NLM
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| 650 |
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|a sigma factor KatF protein, Bacteria
|2 NLM
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| 700 |
1 |
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|a Guo, Lina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Xiaojin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qin, Yingxue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Lingmin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Yongquan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Qingpi
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 42(2019), 5 vom: 05. Mai, Seite 703-712
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnns
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| 773 |
1 |
8 |
|g volume:42
|g year:2019
|g number:5
|g day:05
|g month:05
|g pages:703-712
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| 856 |
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|u http://dx.doi.org/10.1111/jfd.12972
|3 Volltext
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|h 703-712
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