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231225s2019 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/adma.201808200
|2 doi
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|a pubmed24n0979.xml
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|a (NLM)30773718
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Min, Huan
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Biomimetic Metal-Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy
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|c 2019
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 31.07.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Photodynamic therapy (PDT) is a promising anticancer treatment and is clinically approved for different types of tumors. However, current PDT suffers several obstacles, including its neutralization by excess glutathione (GSH) in the tumor tissue and its strongly proangiogenic tumor response. In this work, a biomimic, multifunctional nanoparticle-based PDT agent, combining a tumor-targeted photosensitizer with GSH scavenging and antiangiogenesis therapy, is developed. A porphyrinic Zr-metal-organic framework nanoparticle is used simultaneously as the photosensitizer and the delivery vehicle of vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor apatinib. The core nanoparticles are wrapped in MnO2 to consume the intratumoral GSH and then decorated with a tumor cell membrane camouflage. After intravenous administration, the nanoparticles selectively accumulate in tumor through homotypic targeting mediated by the biomimic decoration, and the combination of enhanced PDT and antiangiogenic drug significantly improves their tumor inhibition efficiency. This study provides an integrated solution for mechanism-based enhancement of PDT and demonstrates the encouraging potential for multifunctional nanosystem applicable for tumor therapy
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|a Journal Article
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4 |
|a MOF
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4 |
|a angiogenesis inhibition
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| 650 |
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|a biomimetic nanoparticle
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| 650 |
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4 |
|a glutathione metabolism
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4 |
|a photodynamic therapy
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| 650 |
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7 |
|a Angiogenesis Inhibitors
|2 NLM
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| 650 |
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7 |
|a Antineoplastic Agents
|2 NLM
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| 650 |
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7 |
|a Metal-Organic Frameworks
|2 NLM
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| 650 |
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7 |
|a Photosensitizing Agents
|2 NLM
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| 700 |
1 |
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|a Wang, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qi, Yingqiu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yinlong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Han, Xuexiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Junchao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Long
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Keman
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Guangna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Na
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yiye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nie, Guangjun
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 15 vom: 12. Apr., Seite e1808200
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
8 |
|g volume:31
|g year:2019
|g number:15
|g day:12
|g month:04
|g pages:e1808200
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| 856 |
4 |
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|u http://dx.doi.org/10.1002/adma.201808200
|3 Volltext
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