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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.8b03882
|2 doi
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|a pubmed25n0979.xml
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|a eng
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|a Chen, Zhuo
|e verfasserin
|4 aut
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|a Engineering the Echogenic Properties of Microfluidic Microbubbles Using Mixtures of Recombinant Protein and Amphiphilic Copolymers
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 21.08.2020
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|a Date Revised 19.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Microbubbles are used as ultrasound contrast agents in medical diagnosis and also have shown great promise in ultrasound-mediated therapy. However, short lifetime and broad size distribution of microbubbles limit their applications in therapy and imaging. Moreover, it is challenging to tailor the echogenic response of microbubbles to make them suitable for specific applications. To overcome these challenges, we use microfluidic flow-focusing to prepare monodisperse microbubbles with a mixture of a recombinant amphiphilic protein, oleosin, and a synthetic amphiphilic copolymer, Pluronic. We show that these microbubbles have superior uniformity and stability under ultrasonic stimulation compared to commercial agents. We also demonstrate that by using different Pluronics, the echogenic response of the microbubbles can be tailored. Our work shows the versatility of using the combination of microfluidics and protein/copolymer mixtures as a method of engineering microbubbles. This tunability could potentially be important and powerful in producing microbubble agents for theranostic applications
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Video-Audio Media
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|a Contrast Media
|2 NLM
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|a Plant Proteins
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|a Recombinant Proteins
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|a Surface-Active Agents
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|a Pulsipher, Katherine W
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|a Chattaraj, Rajarshi
|e verfasserin
|4 aut
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|a Hammer, Daniel A
|e verfasserin
|4 aut
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|a Sehgal, Chandra M
|e verfasserin
|4 aut
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|a Lee, Daeyeon
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 35(2019), 31 vom: 06. Aug., Seite 10079-10086
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|g volume:35
|g year:2019
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|g month:08
|g pages:10079-10086
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|u http://dx.doi.org/10.1021/acs.langmuir.8b03882
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