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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/ery463
|2 doi
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|a pubmed24n0979.xml
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|a (DE-627)NLM293793786
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|a (NLM)30753668
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Schaufelberger, Myriam
|e verfasserin
|4 aut
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|a Mutations in the Arabidopsis ROL17/isopropylmalate synthase 1 locus alter amino acid content, modify the TOR network, and suppress the root hair cell development mutant lrx1
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 12.06.2020
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|a Date Revised 12.06.2020
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Experimental Biology.
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|a The growth and development of organisms must be tightly controlled and adjusted to nutrient availability and metabolic activities. The Target of Rapamycin (TOR) network is a major control mechanism in eukaryotes and influences processes such as translation, mitochondrial activity, production of reactive oxygen species, and the cytoskeleton. In Arabidopsis thaliana, inhibition of the TOR kinase causes changes in cell wall architecture and suppression of phenotypic defects of the cell wall formation mutant lrx1 (leucine-rich repeat extensin 1). The rol17 (repressor of lrx1 17) mutant was identified as a new suppressor of lrx1 that induces also a short root phenotype. The ROL17 locus encodes isopropylmalate synthase 1, a protein involved in leucine biosynthesis. Dependent on growth conditions, mutations in ROL17 do not necessarily alter the level of leucine, but always cause development of the rol17 mutant phenotypes, suggesting that the mutation does not only influence leucine biosynthesis. Changes in the metabolome of rol17 mutants are also found in plants with inhibited TOR kinase activity. Furthermore, rol17 mutants show reduced sensitivity to the TOR kinase inhibitor AZD-8055, indicating a modified TOR network. Together, these data suggest that suppression of lrx1 by rol17 is the result of an alteration of the TOR network
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a rol17
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|a extensin
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|a AZD-8055
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|a Arabidopsis
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|a IPMS1
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|a LRX1
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|a TOR
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|a leucine
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|a root
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|a root hair
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|a Arabidopsis Proteins
|2 NLM
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|a LRX1 protein, Arabidopsis
|2 NLM
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|a Glucosyltransferases
|2 NLM
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| 650 |
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|a EC 2.4.1.-
|2 NLM
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| 650 |
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|a RHM1 protein, Arabidopsis
|2 NLM
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| 650 |
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|a EC 2.4.1.-
|2 NLM
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| 650 |
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|a TOR protein, Arabidopsis
|2 NLM
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| 650 |
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|a EC 2.7.1.137
|2 NLM
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| 650 |
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|a Leucine
|2 NLM
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| 650 |
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|a GMW67QNF9C
|2 NLM
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|a Galbier, Florian
|e verfasserin
|4 aut
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|a Herger, Aline
|e verfasserin
|4 aut
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|a de Brito Francisco, Rita
|e verfasserin
|4 aut
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|a Roffler, Stefan
|e verfasserin
|4 aut
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| 700 |
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|a Clement, Gilles
|e verfasserin
|4 aut
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|a Diet, Anouck
|e verfasserin
|4 aut
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|a Hörtensteiner, Stefan
|e verfasserin
|4 aut
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|a Wicker, Thomas
|e verfasserin
|4 aut
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| 700 |
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|a Ringli, Christoph
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 70(2019), 8 vom: 15. Apr., Seite 2313-2323
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:70
|g year:2019
|g number:8
|g day:15
|g month:04
|g pages:2313-2323
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|u http://dx.doi.org/10.1093/jxb/ery463
|3 Volltext
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|d 70
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|h 2313-2323
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