Extracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis

Extracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis

© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Bibliographische Detailangaben
Veröffentlicht in:Journal of experimental botany. - 1985. - 70(2019), 7 vom: 12. Apr., Seite 2199-2210
1. Verfasser: Escamez, Sacha (VerfasserIn)
Weitere Verfasser: Stael, Simon, Vainonen, Julia P, Willems, Patrick, Jin, Huiting, Kimura, Sachie, Van Breusegem, Frank, Gevaert, Kris, Wrzaczek, Michael, Tuominen, Hannele
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Journal of experimental botany
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Arabidopsis autophagy cell death peptide peptidomics programmed cell death stress response vascular development mehr... xylem AT3G23450 protein, Arabidopsis Arabidopsis Proteins Autophagy-Related Protein 5 RNA-Binding Proteins Reactive Oxygen Species Atg5 protein, Arabidopsis EC 3.1.3.- Caspases EC 3.4.22.- metacaspase 9, Arabidopsis
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100 1 |a Escamez, Sacha  |e verfasserin  |4 aut 
245 1 0 |a Extracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis 
264 1 |c 2019 
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500 |a Citation Status MEDLINE 
520 |a © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Experimental Biology. 
520 |a During plant vascular development, xylem tracheary elements (TEs) form water-conducting, empty pipes by genetically regulated cell death. Cell death is prevented from spreading to non-TEs by unidentified intercellular mechanisms, downstream of METACASPASE9 (MC9)-mediated regulation of autophagy in TEs. Here, we identified differentially abundant extracellular peptides in vascular-differentiating wild-type and MC9-down-regulated Arabidopsis cell suspensions. A peptide named Kratos rescued the abnormally high ectopic non-TE death resulting from either MC9 knockout or TE-specific overexpression of the ATG5 autophagy protein during experimentally induced vascular differentiation in Arabidopsis cotyledons. Kratos also reduced cell death following mechanical damage and extracellular ROS production in Arabidopsis leaves. Stress-induced but not vascular non-TE cell death was enhanced by another identified peptide, named Bia. Bia is therefore reminiscent of several known plant cell death-inducing peptides acting as damage-associated molecular patterns. In contrast, Kratos plays a novel extracellular cell survival role in the context of development and during stress response 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Arabidopsis 
650 4 |a autophagy 
650 4 |a cell death 
650 4 |a peptide 
650 4 |a peptidomics 
650 4 |a programmed cell death 
650 4 |a stress response 
650 4 |a vascular development 
650 4 |a xylem 
650 7 |a AT3G23450 protein, Arabidopsis  |2 NLM 
650 7 |a Arabidopsis Proteins  |2 NLM 
650 7 |a Autophagy-Related Protein 5  |2 NLM 
650 7 |a RNA-Binding Proteins  |2 NLM 
650 7 |a Reactive Oxygen Species  |2 NLM 
650 7 |a Atg5 protein, Arabidopsis  |2 NLM 
650 7 |a EC 3.1.3.-  |2 NLM 
650 7 |a Caspases  |2 NLM 
650 7 |a EC 3.4.22.-  |2 NLM 
650 7 |a metacaspase 9, Arabidopsis  |2 NLM 
650 7 |a EC 3.4.22.-  |2 NLM 
700 1 |a Stael, Simon  |e verfasserin  |4 aut 
700 1 |a Vainonen, Julia P  |e verfasserin  |4 aut 
700 1 |a Willems, Patrick  |e verfasserin  |4 aut 
700 1 |a Jin, Huiting  |e verfasserin  |4 aut 
700 1 |a Kimura, Sachie  |e verfasserin  |4 aut 
700 1 |a Van Breusegem, Frank  |e verfasserin  |4 aut 
700 1 |a Gevaert, Kris  |e verfasserin  |4 aut 
700 1 |a Wrzaczek, Michael  |e verfasserin  |4 aut 
700 1 |a Tuominen, Hannele  |e verfasserin  |4 aut 
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773 1 8 |g volume:70  |g year:2019  |g number:7  |g day:12  |g month:04  |g pages:2199-2210 
856 4 0 |u http://dx.doi.org/10.1093/jxb/erz021  |3 Volltext 
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