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231225s2019 xx |||||o 00| ||eng c |
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|a 10.5713/ajas.18.0827
|2 doi
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|a pubmed24n1441.xml
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|a (DE-627)NLM293701717
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|a (NLM)30744352
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wu, Fen
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Association analysis of polymorphisms of G protein-coupled receptor 54 gene exons with reproductive traits in Jiaxing Black sows
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Revised 15.06.2024
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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| 520 |
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|a OBJECTIVE: The aim of this study was to detect single nucleotide polymorphisms (SNP) of G protein-coupled receptor 54 (GPR54) gene and explore association of this candidate gene with reproductive traits in Jiaxing Black sows
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| 520 |
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|a METHODS: Six pairs of primers of the gene were designed to amplify all exons thus sequences of which were detected by means of direct sequencing and then SNP loci were scanned. The effects of SNPs on total number of piglets born (TNB), number of piglets born alive (NBA), number of still born piglets (NSB), and litter weight at birth (LWB) of Jiaxing Black sows were analyzed
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|a RESULTS: Three SNP loci, including T3739C, C3878T and T6789C, were identified via comparison of sequencing and two genotypes (AB, BB) at each SNP site were observed. T3739C resulted in the change of amino acid (Leu→Pro) in corresponding protein, and C3878T resulted in synonymous mutation (Ile→Ile). Statistical results demonstrated that allele B was the preponderant allele at the three SNP loci and Genotype BB was the preponderant genotype. Meanwhile, Chi-Square test of these three SNPs indicated that all mutation sites fitted in Hardy-Weinberg equilibrium (p>0.05). For GPR54-T3739C locus, Jiaxing Black sows with genotype BB had 1.23 TNB and 1.28 NBA (p<0.01) that were more than those with genotype AB, respectively. Jiaxing Black sows that had the first two parities with genotype BB had additional 2.23 TNB, 2.27 NBA (p<0.01), and 1.94 LWB (p<0.05) compared to those with genotype AB, respectively. However, for other two loci, no significant difference was found between TNB, NBA, NSB, and LWB, and different genotypes of Jiaxing Black sows
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|a CONCLUSION: In conclusion, the polymorphisms of GPR54-T3739C locus were significantly associated to TNB, NBA, and LWB and could be used as a potential genetic marker to improve reproductive function of Jiaxing black sows
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|a Journal Article
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|a G Protein-coupled Receptor 54 (GPR54)
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|a Jiaxing Black Sows
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| 650 |
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|a Reproductive Traits
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| 650 |
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4 |
|a Single Nucleotide Polymorphisms
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| 700 |
1 |
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|a Zhang, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Qian-Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Hai-Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Ming-Shu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Guo-Liang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jin-Zhi
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Asian-Australasian journal of animal sciences
|d 1998
|g 32(2019), 8 vom: 01. Aug., Seite 1104-1111
|w (DE-627)NLM098195883
|x 1011-2367
|7 nnns
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| 773 |
1 |
8 |
|g volume:32
|g year:2019
|g number:8
|g day:01
|g month:08
|g pages:1104-1111
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| 856 |
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|u http://dx.doi.org/10.5713/ajas.18.0827
|3 Volltext
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