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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.12954
|2 doi
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|a pubmed24n0978.xml
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|a (DE-627)NLM293602956
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|a (NLM)30734315
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Foysal, Md Javed
|e verfasserin
|4 aut
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|a Molecular characterization and interactome analysis of aerolysin (aer) gene from fish pathogen Aeromonas veronii
|b The pathogenicity inferred from sequence divergence and linked to histidine kinase (cheA)
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 02.05.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 John Wiley & Sons Ltd.
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|a Aerolysin (aer) is one of the most important and abundant virulence factors in the infection of fish by Aeromonas veronii. A comprehensive study on the molecular characterization and pathogenicity of the aer gene from 34 A. veronii isolates from diseased carp and catfish was carried out and its interactome was analysed to observe the functional correlations between aer and other proteins within the A. veronii network. The PCR-based amplification of aer from the 34 isolates of A. veronii showed more aer-positive isolates from catfish with a high pathogenic potential in the in vivo challenge test than the carp fish. The analysis of aer gene sequence from challenged fish revealed significant sequence divergence according to the types and geographical distribution of the fish. The networking analysis of aer from the model A. veronii B565 revealed histidine kinase (cheA) as the most functional interacting partner. The study of the interaction between aer from the experimental A. veronii and cheA demonstrated that the A chain of cheA plays a more important role than the corresponding B chain during contact, and a linker sequence of 15 residues controlled the entire interaction process. Therefore, cheA could be an excellent drug target for controlling A. veronii infection of fish
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|a Journal Article
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|a A. veronii
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| 650 |
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|a aer
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| 650 |
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|a PCR and sequencing
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| 650 |
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|a bioinformatics
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|a cheA
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|a Bacterial Toxins
|2 NLM
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|a Pore Forming Cytotoxic Proteins
|2 NLM
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| 650 |
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|a Virulence Factors
|2 NLM
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| 650 |
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|a aerolysin
|2 NLM
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| 650 |
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|a 53126-24-2
|2 NLM
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| 650 |
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|a Histidine Kinase
|2 NLM
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| 650 |
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|a EC 2.7.13.1
|2 NLM
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| 700 |
1 |
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|a Momtaz, Farhana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ali, Md Hazrat
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Siddik, Muhammad A B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chaklader, Md Reaz
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rahman, Md Mahbubur
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Prodhan, Md Shamsul Haque
|e verfasserin
|4 aut
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| 700 |
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|a Cole, Anthony
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 42(2019), 4 vom: 01. Apr., Seite 465-475
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnns
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| 773 |
1 |
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|g volume:42
|g year:2019
|g number:4
|g day:01
|g month:04
|g pages:465-475
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| 856 |
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|u http://dx.doi.org/10.1111/jfd.12954
|3 Volltext
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