Modular Metal-Organic Polyhedra Superassembly From Molecular-Level Design to Targeted Drug Delivery

Modular Metal-Organic Polyhedra Superassembly : From Molecular-Level Design to Targeted Drug Delivery

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 31(2019), 12 vom: 30. März, Seite e1806774
1. Verfasser: Zhu, Wei (VerfasserIn)
Weitere Verfasser: Guo, Jimin, Ju, Yi, Serda, Rita E, Croissant, Jonas G, Shang, Jin, Coker, Eric, Agola, Jacob Ongudi, Zhong, Qi-Zhi, Ping, Yuan, Caruso, Frank, Brinker, C Jeffrey
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article metal-organic polyhedra micelles nanoparticles superassembly targeted drug delivery Antineoplastic Agents Delayed-Action Preparations Drug Carriers Macromolecular Substances mehr... Metals Micelles Organometallic Compounds Doxorubicin 80168379AG ErbB Receptors EC 2.7.10.1
Beschreibung
Zusammenfassung:© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal-organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well-defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one-pot process for versatile bioapplications. The MOP superassemblies are surface-engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half-life of 5.6 h and to undergo renal clearance-characteristics needed for nanomedicines
Beschreibung:Date Completed 27.11.2019
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201806774