Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties

Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 31(2019), 12 vom: 12. März, Seite e1806727
Auteur principal: Hörner, Maximilian (Auteur)
Autres auteurs: Raute, Katrin, Hummel, Barbara, Madl, Josef, Creusen, Guido, Thomas, Oliver S, Christen, Erik H, Hotz, Natascha, Gübeli, Raphael J, Engesser, Raphael, Rebmann, Balder, Lauer, Jasmin, Rolauffs, Bernd, Timmer, Jens, Schamel, Wolfgang W A, Pruszak, Jan, Römer, Winfried, Zurbriggen, Matias D, Friedrich, Christian, Walther, Andreas, Minguet, Susana, Sawarkar, Ritwick, Weber, Wilfried
Format: Article en ligne
Langue:English
Publié: 2019
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article biomaterials cell migration extracellular matrix mechanosignaling optogenetics phytochromes
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520 |a Interrogation and control of cellular fate and function using optogenetics is providing revolutionary insights into biology. Optogenetic control of cells is achieved by coupling genetically encoded photoreceptors to cellular effectors and enables unprecedented spatiotemporal control of signaling processes. Here, a fast and reversibly switchable photoreceptor is used to tune the mechanical properties of polymer materials in a fully reversible, wavelength-specific, and dose- and space-controlled manner. By integrating engineered cyanobacterial phytochrome 1 into a poly(ethylene glycol) matrix, hydrogel materials responsive to light in the cell-compatible red/far-red spectrum are synthesized. These materials are applied to study in human mesenchymal stem cells how different mechanosignaling pathways respond to changing mechanical environments and to control the migration of primary immune cells in 3D. This optogenetics-inspired matrix allows fundamental questions of how cells react to dynamic mechanical environments to be addressed. Further, remote control of such matrices can create new opportunities for tissue engineering or provide a basis for optically stimulated drug depots 
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650 4 |a cell migration 
650 4 |a extracellular matrix 
650 4 |a mechanosignaling 
650 4 |a optogenetics 
650 4 |a phytochromes 
700 1 |a Raute, Katrin  |e verfasserin  |4 aut 
700 1 |a Hummel, Barbara  |e verfasserin  |4 aut 
700 1 |a Madl, Josef  |e verfasserin  |4 aut 
700 1 |a Creusen, Guido  |e verfasserin  |4 aut 
700 1 |a Thomas, Oliver S  |e verfasserin  |4 aut 
700 1 |a Christen, Erik H  |e verfasserin  |4 aut 
700 1 |a Hotz, Natascha  |e verfasserin  |4 aut 
700 1 |a Gübeli, Raphael J  |e verfasserin  |4 aut 
700 1 |a Engesser, Raphael  |e verfasserin  |4 aut 
700 1 |a Rebmann, Balder  |e verfasserin  |4 aut 
700 1 |a Lauer, Jasmin  |e verfasserin  |4 aut 
700 1 |a Rolauffs, Bernd  |e verfasserin  |4 aut 
700 1 |a Timmer, Jens  |e verfasserin  |4 aut 
700 1 |a Schamel, Wolfgang W A  |e verfasserin  |4 aut 
700 1 |a Pruszak, Jan  |e verfasserin  |4 aut 
700 1 |a Römer, Winfried  |e verfasserin  |4 aut 
700 1 |a Zurbriggen, Matias D  |e verfasserin  |4 aut 
700 1 |a Friedrich, Christian  |e verfasserin  |4 aut 
700 1 |a Walther, Andreas  |e verfasserin  |4 aut 
700 1 |a Minguet, Susana  |e verfasserin  |4 aut 
700 1 |a Sawarkar, Ritwick  |e verfasserin  |4 aut 
700 1 |a Weber, Wilfried  |e verfasserin  |4 aut 
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