Population genomics demystifies the defoliation phenotype in the plant pathogen Verticillium dahliae

Population genomics demystifies the defoliation phenotype in the plant pathogen Verticillium dahliae

© 2019 The Authors. New Phytologist © 2019 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 222(2019), 2 vom: 04. Apr., Seite 1012-1029
1. Verfasser: Zhang, Dan-Dan (VerfasserIn)
Weitere Verfasser: Wang, Jie, Wang, Dan, Kong, Zhi-Qiang, Zhou, Lei, Zhang, Geng-Yun, Gui, Yue-Jing, Li, Jun-Jiao, Huang, Jin-Qun, Wang, Bao-Li, Liu, Chun, Yin, Chun-Mei, Li, Rui-Xing, Li, Ting-Gang, Wang, Jin-Long, Short, Dylan P G, Klosterman, Steven J, Bostock, Richard M, Subbarao, Krishna V, Chen, Jie-Yin, Dai, Xiao-Feng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Verticillium dahliae N-acylethanolamines (NAEs) defoliating phenotype lineage-specific genes secondary metabolites Ethanolamines Lauric Acids N-lauroylethanolamine 142-78-9
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500 |a Citation Status MEDLINE 
520 |a © 2019 The Authors. New Phytologist © 2019 New Phytologist Trust. 
520 |a Verticillium dahliae is a broad host-range pathogen that causes vascular wilts in plants. Interactions between three hosts and specific V. dahliae genotypes result in severe defoliation. The underlying mechanisms of defoliation are unresolved. Genome resequencing, gene deletion and complementation, gene expression analysis, sequence divergence, defoliating phenotype identification, virulence analysis, and quantification of V. dahliae secondary metabolites were performed. Population genomics previously revealed that G-LSR2 was horizontally transferred from the fungus Fusarium oxysporum f. sp. vasinfectum to V. dahliae and is exclusively found in the genomes of defoliating (D) strains. Deletion of seven genes within G-LSR2, designated as VdDf genes, produced the nondefoliation phenotype on cotton, olive, and okra but complementation of two genes restored the defoliation phenotype. Genes VdDf5 and VdDf6 associated with defoliation shared homology with polyketide synthases involved in secondary metabolism, whereas VdDf7 shared homology with proteins involved in the biosynthesis of N-lauroylethanolamine (N-acylethanolamine (NAE) 12:0), a compound that induces defoliation. NAE overbiosynthesis by D strains also appears to disrupt NAE metabolism in cotton by inducing overexpression of fatty acid amide hydrolase. The VdDfs modulate the synthesis and overproduction of secondary metabolites, such as NAE 12:0, that cause defoliation either by altering abscisic acid sensitivity, hormone disruption, or sensitivity to the pathogen 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Verticillium dahliae 
650 4 |a N-acylethanolamines (NAEs) 
650 4 |a defoliating phenotype 
650 4 |a lineage-specific genes 
650 4 |a secondary metabolites 
650 7 |a Ethanolamines  |2 NLM 
650 7 |a Lauric Acids  |2 NLM 
650 7 |a N-lauroylethanolamine  |2 NLM 
650 7 |a 142-78-9  |2 NLM 
700 1 |a Wang, Jie  |e verfasserin  |4 aut 
700 1 |a Wang, Dan  |e verfasserin  |4 aut 
700 1 |a Kong, Zhi-Qiang  |e verfasserin  |4 aut 
700 1 |a Zhou, Lei  |e verfasserin  |4 aut 
700 1 |a Zhang, Geng-Yun  |e verfasserin  |4 aut 
700 1 |a Gui, Yue-Jing  |e verfasserin  |4 aut 
700 1 |a Li, Jun-Jiao  |e verfasserin  |4 aut 
700 1 |a Huang, Jin-Qun  |e verfasserin  |4 aut 
700 1 |a Wang, Bao-Li  |e verfasserin  |4 aut 
700 1 |a Liu, Chun  |e verfasserin  |4 aut 
700 1 |a Yin, Chun-Mei  |e verfasserin  |4 aut 
700 1 |a Li, Rui-Xing  |e verfasserin  |4 aut 
700 1 |a Li, Ting-Gang  |e verfasserin  |4 aut 
700 1 |a Wang, Jin-Long  |e verfasserin  |4 aut 
700 1 |a Short, Dylan P G  |e verfasserin  |4 aut 
700 1 |a Klosterman, Steven J  |e verfasserin  |4 aut 
700 1 |a Bostock, Richard M  |e verfasserin  |4 aut 
700 1 |a Subbarao, Krishna V  |e verfasserin  |4 aut 
700 1 |a Chen, Jie-Yin  |e verfasserin  |4 aut 
700 1 |a Dai, Xiao-Feng  |e verfasserin  |4 aut 
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