RNA editing mutants as surrogates for mitochondrial SNP mutants

Détails bibliographiques
Publié dans:	Plant physiology and biochemistry : PPB. - 1991. - 135(2019) vom: 15. Feb., Seite 310-321
Auteur principal:	Takenaka, Mizuki (Auteur)
Autres auteurs:	Jörg, Anja, Burger, Matthias, Haag, Sascha
Format:	Article en ligne
Langue:	English
Publié:	2019
Accès à la collection:	Plant physiology and biochemistry : PPB
Sujets:	Journal Article Review Mitochondria PPR proteins RNA editing Surrogate mutants Plant Proteins

Description
Résumé:	Copyright © 2018 Elsevier Masson SAS. All rights reserved. In terrestrial plants, RNA editing converts specific cytidines to uridines in mitochondrial and plastidic transcripts. Most of these events appear to be important for proper function of organellar encoded genes, since translated proteins from edited mRNAs show higher similarity with evolutionary conserved polypeptide sequences. So far about 100 nuclear encoded proteins have been characterized as RNA editing factors in plant organelles. Respective RNA editing mutants reduce or lose editing activity at different sites and display various macroscopic phenotypes from pale or albino in the case of chloroplasts to growth retardation or even embryonic lethality. Therefore, RNA editing mutants can be a useful resource of surrogate mutants for organellar encoded genes, especially for mitochondrially encoded genes that it is so far unfeasible to manipulate. However, connections between RNA editing defects and observed phenotypes in the mutants are often hard to elucidate, since RNA editing factors often target multiple RNA sites in different genes simultaneously. In this review article, we summarize the physiological aspects of respective RNA editing mutants and discuss them as surrogate mutants for functional analysis of mitochondrially encoded genes
Description:	Date Completed 22.01.2019 Date Revised 30.09.2020 published: Print-Electronic Citation Status MEDLINE
ISSN:	1873-2690
DOI:	10.1016/j.plaphy.2018.12.014