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20231225072527.0 |
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cr uuu---uuuuu |
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231225s2019 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1002/adma.201806024
|2 doi
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5 |
2 |
|a pubmed24n0973.xml
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|a (DE-627)NLM292183976
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|a (NLM)30589118
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhao, Yu
|e verfasserin
|4 aut
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| 245 |
1 |
2 |
|a A Biomimetic Non-Antibiotic Approach to Eradicate Drug-Resistant Infections
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| 264 |
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1 |
|c 2019
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 30.05.2019
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| 500 |
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|a Date Revised 12.10.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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| 520 |
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|a The chronic infections by pathogenic Pseudomonas aeruginosa (P. aeruginosa) remain to be properly addressed. In particular, for drug-resistant strains, limited medication is available. An in vivo pneumonia model induced by a clinically isolated aminoglycoside resistant strain of P. aeruginosa is developed. Tobramycin clinically treating P. aeruginosa infections is found to be ineffective to inhibit or eliminate this drug-resistant strain. Here, a newly developed non-antibiotics based nanoformulation plus near-infrared (NIR) photothermal treatment shows a remarkable antibacterial efficacy in treating this drug-resistant pneumonia. The novel formulation contains 50-100 nm long nanorods decorated with two types of glycomimetic polymers to specifically block bacterial LecA and LecB lectins, respectively, which are essential for bacterial biofilm development. Such a 3D display of heteromultivalent glycomimetics on a large scale is inspired by the natural strengthening mechanism for the carbohydrate-lectin interaction that occurs when bacteria initially infects the host. This novel formulation shows the most efficient bacteria inhabitation and killing against P. aeruginosa infection, through lectin blocking and the near-infrared-light-induced photothermal effect of gold nanorods, respectively. Collectively, the novel biomimetic design combined with the photothermal killing capability is expected to be an alternative treatment strategy against the ever-threatening drug-resistant infectious diseases when known antibiotics have failed
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4 |
|a Journal Article
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4 |
|a anti-adhesion
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| 650 |
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4 |
|a biofilm inhibition
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| 650 |
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4 |
|a heteromultivalency
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| 650 |
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4 |
|a photothermal therapy
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| 650 |
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4 |
|a pneumonia
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| 650 |
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4 |
|a subcutaneous abscesses
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| 650 |
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7 |
|a Adhesins, Bacterial
|2 NLM
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| 650 |
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7 |
|a Gold Compounds
|2 NLM
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| 650 |
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7 |
|a LecA protein, bacteria
|2 NLM
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| 650 |
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7 |
|a LecB protein, Pseudomonas aeruginosa
|2 NLM
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| 650 |
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7 |
|a Lectins
|2 NLM
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| 650 |
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7 |
|a Polymethacrylic Acids
|2 NLM
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| 650 |
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7 |
|a poly(2-lactobionamidoethyl methacrylamide)
|2 NLM
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| 650 |
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7 |
|a poly(2-perfluorooctylethyl methacrylate )
|2 NLM
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| 650 |
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7 |
|a Lactose
|2 NLM
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| 650 |
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7 |
|a J2B2A4N98G
|2 NLM
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| 700 |
1 |
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|a Guo, Qianqian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dai, Xiaomei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wei, Xiaosong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Yunjian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xuelei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Chaoxing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cao, Zhiqiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xinge
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 7 vom: 05. Feb., Seite e1806024
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
8 |
|g volume:31
|g year:2019
|g number:7
|g day:05
|g month:02
|g pages:e1806024
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.201806024
|3 Volltext
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 31
|j 2019
|e 7
|b 05
|c 02
|h e1806024
|