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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.4818
|2 doi
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|a pubmed24n0973.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Alvarenga, Elson S
|e verfasserin
|4 aut
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| 245 |
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|a Computation and structural elucidation of compounds formed via epoxide alcoholysis
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 16.09.2019
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|a Date Revised 16.09.2019
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © 2018 John Wiley & Sons, Ltd.
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|a Isobenzofuranones are known for their wide range of biological activities such as fungicide, insecticide, and anticancer. The search for novel bioactive compounds was performed by reaction of epoxide 2 with methanol, ethanol, propan-1-ol, propan-2-ol, and butan-1-ol. The mechanism for the stereoselective and stereospecific epoxide opening with methanol was reasoned by calculating the transition states for the two putative structures (rac)-3a and (rac)-3b. The compound (rac)-3a is the kinetic product as inferred from the lower energies of its transition state (TS1). The 1 H and 13 C nuclear magnetic resonance (NMR) chemical shifts for these two candidate structures were calculated and compared with the experimental data using mean absolute error (MAE) and DP4 analyses. Therefore, the relative stereochemistry of (rac)-3a was established by the mechanism, MAE, and DP4 approaches. The hydroxyl group was acetylated to surpass the problem of signal overlapping of H5 and H6 in the 1 H NMR. The relative stereochemistry of the corresponding ester determined by NMR interpretation was in agreement with the structure of (rac)-3a
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 13C NMR
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|a 1H NMR
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|a DP4
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|a MAE
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|a epoxide
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|a isobenzofuranone
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4 |
|a phthalides
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|a γ-lactones
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1 |
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|a Teixeira, Milena G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lopes, Dayane T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Demuner, Antonio J
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 57(2019), 4 vom: 30. Apr., Seite S101-S107
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
1 |
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|g volume:57
|g year:2019
|g number:4
|g day:30
|g month:04
|g pages:S101-S107
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|u http://dx.doi.org/10.1002/mrc.4818
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