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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.8b03693
|2 doi
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|a pubmed25n0973.xml
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|a (NLM)30567432
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Lu, Qian
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Folate-Conjugated Cell Membrane Mimetic Polymer Micelles for Tumor-Cell-Targeted Delivery of Doxorubicin
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 03.12.2019
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|a Date Revised 03.12.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Tumor-targeting nano-drug-delivery systems hold great potential to improve the therapeutic efficacy and alleviate the side effects of cancer treatments. Herein, folic acid (FA)-decorated amphiphilic copolymer of FA-P(MPC- co-MaPCL) (MPC: 2-methacryloxoethyl phosphorylcholine, MaPCL: poly(ε-caprolactone) macromonomer) is synthesized and its micelles are fabricated for doxorubicin (DOX) delivery. And non-FA-decorated P(MPC- co-MaPCL) micelles are used as the control. Dynamic light scattering and scanning electron microscopy measurements reveal that FA-P(MPC- co-MaPCL) and P(MPC- co-MaPCL) micelles are spherical with average diameters of 140 and 90 nm, respectively. The evaluation in vitro demonstrates that the blank micelles are nontoxic, while DOX-loaded FA-P(MPC- co-MaPCL) micelles show significant cytotoxicity to HeLa cells and slight cytotoxicity to L929 cells. Moreover, the cellular uptake of DOX-loaded FA-P(MPC- co-MaPCL) micelles in HeLa cells are 4.3-fold and 1.7-fold higher than that of DOX-loaded P(MPC- co-MaPCL) micelles and free DOX after 6 h of incubation, respectively. These results indicate the great potential of this system in anticancer target drug-delivery applications
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antineoplastic Agents
|2 NLM
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|a Drug Carriers
|2 NLM
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|a Micelles
|2 NLM
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| 650 |
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|a Polymers
|2 NLM
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|a Doxorubicin
|2 NLM
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| 650 |
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|a 80168379AG
|2 NLM
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| 650 |
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|a Folic Acid
|2 NLM
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| 650 |
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|a 935E97BOY8
|2 NLM
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| 700 |
1 |
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|a Yi, Meijun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Mengchen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Zhangyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Shiping
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 35(2019), 2 vom: 15. Jan., Seite 504-512
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:35
|g year:2019
|g number:2
|g day:15
|g month:01
|g pages:504-512
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|u http://dx.doi.org/10.1021/acs.langmuir.8b03693
|3 Volltext
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