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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2018.12.012
|2 doi
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|a pubmed24n0972.xml
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|a (DE-627)NLM291739059
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|a (NLM)30543925
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|a (PII)S1521-6616(18)30722-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Tiosano, Shmuel
|e verfasserin
|4 aut
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|a The long-term prognostic significance of sarcoidosis-associated pulmonary hypertension - A cohort study
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|c 2019
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 02.12.2019
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|a Date Revised 02.12.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2018 Elsevier Inc. All rights reserved.
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|a BACKGROUND: Sarcoidosis is a multisystem, chronic, progressive, granulomatous disease. Sarcoidosis-associated pulmonary hypertension is a well described, but not common, complication of sarcoidosis. In small scale studies, it has been previously described as manifestation of advanced disease and was found to be associated increased morbidity and mortality. This study sought to assess the long-term prognostic significance of sarcoidosis-associated pulmonary hypertension (SAPH) by using data obtained from a large population-based registry which contains longitudinal follow-up data
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|a METHODS: Utilizing the records of the largest healthcare provider in Israel, we extracted a cohort consisting of sarcoidosis patients and age-and-sex matched controls. Dates of sarcoidosis registration, pulmonary hypertension and death, as well as anthropometric information and medical comorbidities, were extracted from the database. A multivariate logistic regression model was used to find variables associated with pulmonary hypertension. Cox proportional hazards method and log-rank test were used for survival analysis
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|a RESULTS: The cohort included 3993 sarcoidosis patients and 19,856 controls. Pulmonary hypertension was observed among 269 sarcoidosis patients (6.74%) vs. 400 controls (2.01%). Sarcoidosis was found as independently associated with pulmonary hypertension (OR 3.17). After a mean follow-up of 7.49 years (median 7.24, maximum 17.88 years), 710 (17.8%) of the sarcoidosis patients and 2121 (10.7%) of the controls had died. Both sarcoidosis and pulmonary hypertension were found to be significantly associated with an increased risk of all-cause mortality (HR 1.82 and HR 2.31, respectively)
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|a CONCLUSIONS: SAPH is associated with a poor prognosis. Proper screening methods may assess whether early identification and treatment improve life expectancy
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|a Journal Article
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|a Cohort
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|a Prognosis
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|a Pulmonary hypertension
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|a Sarcoidosis
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| 650 |
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4 |
|a Survival
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| 700 |
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|a Versini, Mathilde
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dar Antaki, Lior
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Spitzer, Liron
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yavne, Yarden
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Watad, Abdulla
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gendelman, Omer
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Comaneshter, Doron
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cohen, Arnon D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Amital, Howard
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 199(2019) vom: 10. Feb., Seite 57-61
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:199
|g year:2019
|g day:10
|g month:02
|g pages:57-61
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2018.12.012
|3 Volltext
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