|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM291474411 |
| 003 |
DE-627 |
| 005 |
20231225070943.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2019 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.201806202
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0971.xml
|
| 035 |
|
|
|a (DE-627)NLM291474411
|
| 035 |
|
|
|a (NLM)30516854
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Lang, Tianqun
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Cocktail Strategy Based on Spatio-Temporally Controlled Nano Device Improves Therapy of Breast Cancer
|
| 264 |
|
1 |
|c 2019
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 30.04.2019
|
| 500 |
|
|
|a Date Revised 30.09.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a ErratumIn: Adv Mater. 2019 Aug;31(33):e1903844. - PMID 31407841
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
|
| 520 |
|
|
|a Metastatic breast cancer may be resistant to chemo-immunotherapy due to the existence of cancer stem cells (CSC). Also, the control of particle size and drug release of a drug carrier for multidrug combination is a key issue influencing the therapy effect. Here, a cocktail strategy is reported, in which chemotherapy against both bulk tumor cells and CSC and immune checkpoint blockade therapy are intergraded into one drug delivery system. The chemotherapeutic agent paclitaxel (PTX), the anti-CSC agent thioridazine (THZ), and the PD-1/PD-L1 inhibitor HY19991 (HY) are all incorporated into an enzyme/pH dual-sensitive nanoparticle with a micelle-liposome double-layer structure. The particle size shrinks when the nanoparticle transfers from circulation to tumor tissues, favoring both pharmacokinetics and cellular uptake, meanwhile achieving sequential drug release where needed. This nano device, named PMTHL, increases the intratumoral drug concentrations in mice and exhibits significant anticancer efficacy, with tumor inhibiting rate of 93.45% and lung metastasis suppression rate of 97.64%. It also reduces the proportion of CSC and enhances the T cells infiltration in tumor tissues, and thus prolongs the survival of mice. The cocktail therapy based on the spatio-temporally controlled nano device will be a promising strategy for treating breast cancer
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a breast cancer
|
| 650 |
|
4 |
|a cancer stem cells
|
| 650 |
|
4 |
|a chemotherapy
|
| 650 |
|
4 |
|a immunotherapy
|
| 650 |
|
4 |
|a nano device
|
| 650 |
|
7 |
|a Antineoplastic Agents
|2 NLM
|
| 650 |
|
7 |
|a Drug Carriers
|2 NLM
|
| 650 |
|
7 |
|a Micelles
|2 NLM
|
| 650 |
|
7 |
|a Matrix Metalloproteinase 9
|2 NLM
|
| 650 |
|
7 |
|a EC 3.4.24.35
|2 NLM
|
| 650 |
|
7 |
|a Thioridazine
|2 NLM
|
| 650 |
|
7 |
|a N3D6TG58NI
|2 NLM
|
| 650 |
|
7 |
|a Paclitaxel
|2 NLM
|
| 650 |
|
7 |
|a P88XT4IS4D
|2 NLM
|
| 700 |
1 |
|
|a Liu, Yiran
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zheng, Zhong
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ran, Wei
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhai, Yihui
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yin, Qi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Pengcheng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Yaping
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 5 vom: 15. Feb., Seite e1806202
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
|
| 773 |
1 |
8 |
|g volume:31
|g year:2019
|g number:5
|g day:15
|g month:02
|g pages:e1806202
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.201806202
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 31
|j 2019
|e 5
|b 15
|c 02
|h e1806202
|