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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.plantsci.2018.09.019
|2 doi
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|a pubmed25n0969.xml
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|a (DE-627)NLM290980488
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|a (NLM)30466590
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|a (PII)S0168-9452(18)30794-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Arraño-Salinas, Paulina
|e verfasserin
|4 aut
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| 245 |
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|a WRKY7, -11 and -17 transcription factors are modulators of the bZIP28 branch of the unfolded protein response during PAMP-triggered immunity in Arabidopsis thaliana
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 17.12.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2018 Elsevier B.V. All rights reserved.
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|a Plants must defend themselves against pathogens. The defense response requires greater protein synthesis, which generates endoplasmic reticulum (ER) stress, yet failure to attenuate this stress has detrimental effects. WRKY7/11/17 transcription factors (TFs) are negative regulators of immunity since mutants are more resistant to Pseudomonas syringae pv tomato (Pst) infection. Here, we reveal a connection between ER-stress and the molecular mechanisms underlying the wrky mutant phenotype. The bZIP28 TF upregulates ER-chaperone expression (BiP1/2, ERdj3B, and SDF2) upon exposure of Arabidopsis to a bacterial defense elicitor, flagellin 22 (Flg22). Also, the activation of ER-chaperones is more sustained in double and triple wrky mutants treated with Flg22, suggesting that WRKY7/11/17 TFs downregulate these genes. Moreover, wrky mutants accumulate more bZIP28 transcripts in response to Flg22, indicating that WRKY7/11/17 transcriptionally repress this TF. Using Arabidopsis protoplasts, we also demonstrate that WRKYs bind to the bZIP28 promoter via W-box elements. Additionally, triple wrky mutants are more resistant, whilst bzip28 mutants are more susceptible, to Pst infection. Finally, we postulate a model of PAMP-Triggered Immunity regulation, where Flg22 activates bZIP28-signaling inducing the expression of ER-stress genes, as well as WRKY7/11/17 expression, which in turn inhibits PTI by downregulating bZIP28, controlling physiological responses in the Arabidopsis-Pst interaction
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|a Journal Article
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|a Basal defense response
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|a Flg22
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|a Unfolded protein response
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|a WRKY
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|a bZIP
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|a Arabidopsis Proteins
|2 NLM
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| 650 |
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|a Basic-Leucine Zipper Transcription Factors
|2 NLM
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| 650 |
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|a Transcription Factors
|2 NLM
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| 700 |
1 |
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|a Domínguez-Figueroa, José
|e verfasserin
|4 aut
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| 700 |
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|a Herrera-Vásquez, Ariel
|e verfasserin
|4 aut
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| 700 |
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|a Zavala, Diego
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Medina, Joaquin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vicente-Carbajosa, Jesús
|e verfasserin
|4 aut
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| 700 |
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|a Meneses, Claudio
|e verfasserin
|4 aut
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| 700 |
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|a Canessa, Paulo
|e verfasserin
|4 aut
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| 700 |
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|a Moreno, Adrián A
|e verfasserin
|4 aut
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| 700 |
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|a Blanco-Herrera, Francisca
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Plant science : an international journal of experimental plant biology
|d 1985
|g 277(2018) vom: 27. Dez., Seite 242-250
|w (DE-627)NLM098174193
|x 1873-2259
|7 nnns
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| 773 |
1 |
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|g volume:277
|g year:2018
|g day:27
|g month:12
|g pages:242-250
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| 856 |
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|u http://dx.doi.org/10.1016/j.plantsci.2018.09.019
|3 Volltext
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|a AR
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|d 277
|j 2018
|b 27
|c 12
|h 242-250
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