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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.plantsci.2018.09.011
|2 doi
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|a pubmed24n0969.xml
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|a (DE-627)NLM290980437
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|a (NLM)30466585
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|a (PII)S0168-9452(18)30771-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Migocka, Magdalena
|e verfasserin
|4 aut
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|a Cucumber Golgi protein CsMTP5 forms a Zn-transporting heterodimer with high molecular mass protein CsMTP12
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 17.12.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2018 Elsevier B.V. All rights reserved.
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|a Heterodimeric complexes formed by members of the cation facilitator (CDF) family catalyse the import of Zn into the secretory pathway of yeast and vertebrate cells. Orthologous proteins AtMTP5 and AtMTP12 from Arabidopsis have also been shown to form a heterodimeric complex at the Golgi compartment of plant cells that possibly transport Zn. In this study we show that cucumber proteins CsMTP5 and CsMTP12 form a functional heterodimer that is involved in the loading of Zn into the ER lumen under low Zn, and not in the detoxification of yeast from Zn excess through vesicle-mediated exocytosis. Using specific antibodies, we demonstrate that CsMTP5 is localized at the Golgi compartment of cucumber cells and is markedly up-regulated upon Zn deficiency. The level of CsMTP5 transcript in cucumber is also significantly elevated in Zn-limiting conditions, whereas the expression of CsMTP12 is independent of the availability of Zn. Therefore we propose that the cucumber heterodimeric complex CsMTP5-CsMTP12 functions to deliver Zn to Zn-dependent proteins of the Golgi compartment and is regulated by zinc at the level of CsMTP5 transcription
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|a Journal Article
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|a CDF (cation diffusion facilitator) family
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4 |
|a Cucumis sativus
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4 |
|a Golgi
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4 |
|a MTP (metal tolerance protein) family
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| 650 |
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|a Secretory pathway
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| 650 |
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|a Zinc
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| 650 |
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|a Plant Proteins
|2 NLM
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| 650 |
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|a Zinc
|2 NLM
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| 650 |
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7 |
|a J41CSQ7QDS
|2 NLM
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| 700 |
1 |
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|a Małas, Karolina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maciaszczyk-Dziubinska, Ewa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Posyniak, Ewelina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Migdal, Iwona
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Szczech, Patryk
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Plant science : an international journal of experimental plant biology
|d 1985
|g 277(2018) vom: 27. Dez., Seite 196-206
|w (DE-627)NLM098174193
|x 1873-2259
|7 nnns
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| 773 |
1 |
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|g volume:277
|g year:2018
|g day:27
|g month:12
|g pages:196-206
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|u http://dx.doi.org/10.1016/j.plantsci.2018.09.011
|3 Volltext
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|d 277
|j 2018
|b 27
|c 12
|h 196-206
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