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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.8b03378
|2 doi
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|a pubmed24n0969.xml
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|a (DE-627)NLM290857805
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|a (NLM)30453736
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Martí, Didac
|e verfasserin
|4 aut
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| 245 |
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|a Amyloid-like Fibrils from a Diphenylalanine Capped with an Aromatic Fluorenyl
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 03.04.2019
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|a Date Revised 04.12.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The self-assembly behavior of a diphenylalanine amphiphile blocked at the C-terminus with a 9-fluorenylmethyl ester and stabilized at the N-terminus with a trifluoroacetate (TFA) anion, TFA·FF-OFm, has been examined. At low peptide concentration (0.5 mg/mL), long amyloid-like fibrils, which come from the fusion of two or more helical ribbons and/or thinner fibrils, organized in bundles or as individual entities are detected. Microbeam synchrotron radiation infrared spectroscopy has shown that TFA·FF-OFm molecules in amyloid-like fibrils arrange, forming antiparallel β-sheets. Alteration of the experimental conditions to prioritize the thermodynamic contribution with respect to the kinetic one in the self-assembly process inhibits the organization of amyloid-like structures in favor of the formation of conventional fibrous structures. On the basis of experimental observations, a structural model where the individual antiparallel β-sheets are oriented in parallel has been proposed for TFA·FF-OFm amyloid-like fibrils
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Dipeptides
|2 NLM
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|a Fluorenes
|2 NLM
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|a Peptides
|2 NLM
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|a phenylalanylphenylalanine
|2 NLM
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|a 2577-40-4
|2 NLM
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|a Phenylalanine
|2 NLM
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| 650 |
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|a 47E5O17Y3R
|2 NLM
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1 |
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|a Mayans, Enric
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gil, Ana M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Díaz, Angélica
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiménez, Ana I
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yousef, Ibraheem
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Keridou, Ina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cativiela, Carlos
|e verfasserin
|4 aut
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| 700 |
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|a Puiggalí, Jordi
|e verfasserin
|4 aut
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| 700 |
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|a Alemán, Carlos
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 34(2018), 50 vom: 18. Dez., Seite 15551-15559
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:34
|g year:2018
|g number:50
|g day:18
|g month:12
|g pages:15551-15559
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|u http://dx.doi.org/10.1021/acs.langmuir.8b03378
|3 Volltext
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