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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201804971
|2 doi
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|a pubmed24n0969.xml
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|a eng
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1 |
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|a Li, Li-Li
|e verfasserin
|4 aut
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|a Programmable Construction of Peptide-Based Materials in Living Subjects
|b From Modular Design and Morphological Control to Theranostics
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|c 2019
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|a Text
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|a ƒaComputermedien
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|a Date Completed 31.03.2020
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Self-assembled nanomaterials show potential high efficiency as theranostics for high-performance bioimaging and disease treatment. However, the superstructures of pre-assembled nanomaterials may change in the complicated physiological conditions, resulting in compromised properties and/or biofunctions. Taking advantage of chemical self-assembly and biomedicine, a new strategy of "in vivo self-assembly" is proposed to in situ construct functional nanomaterials in living subjects to explore new biological effects. Herein, recent advances on peptide-based nanomaterials constructed by the in vivo self-assembly strategy are summarized. Modular peptide building blocks with various functions, such as targeting, self-assembly, tailoring, and biofunctional motifs, are employed for the construction of nanomaterials. Then, self-assembly of these building blocks in living systems to construct various morphologies of nanostructures and corresponding unique biological effects, such as assembly/aggregation-induced retention (AIR), are introduced, followed by their applications in high-performance drug delivery and bioimaging. Finally, an outlook and perspective toward future developments of in vivo self-assembled peptide-based nanomaterials for translational medicine are concluded
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|a Journal Article
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|a Review
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|a bioimaging
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|a drug delivery
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|a peptides
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|a programmable
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|a self-assembly
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|a Peptides
|2 NLM
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|a Qiao, Zeng-Ying
|e verfasserin
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|a Wang, Lei
|e verfasserin
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|a Wang, Hao
|e verfasserin
|4 aut
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 45 vom: 01. Nov., Seite e1804971
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|x 1521-4095
|7 nnns
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|g volume:31
|g year:2019
|g number:45
|g day:01
|g month:11
|g pages:e1804971
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|u http://dx.doi.org/10.1002/adma.201804971
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