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231225s2019 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2018.11.004
|2 doi
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|a pubmed25n0968.xml
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|a (NLM)30419354
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|a eng
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| 100 |
1 |
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|a Touzani, Fahd
|e verfasserin
|4 aut
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| 245 |
1 |
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|a New insights into immune cells cross-talk during IgG4-related disease
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 28.10.2019
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|a Date Revised 28.10.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2018 Elsevier Inc. All rights reserved.
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|a Immunoglobulin G4-related disease (IgG4-RD) is a newly acknowledged entity, characterized by an immune-mediated fibro-inflammatory process affecting virtually all organs, with infiltration of IgG4+ bearing plasma cells. Until today the pathogenesis of IgG4-RD remains unknown. Treatment with anti-CD20 monoclonal antibodies efficiently induced remission and attenuated the secretory phenotype of myofibroblasts responsible of uncontrolled collagen deposition. This supports the pathogenic role of the adaptive immunity, particularly B cell compartment and B cell/T cell interaction. Latest studies have also highlighted the importance of innate immune system that has been underestimated before and the key role of a specific T cell subset, T follicular helper cells that are involved in IgG4-class-switching and plasmablast differentiation. In this review, we aim to review the most recent knowledge of innate immunity, T and B cells involvement in IgG4-RD, and introduce tertiary lymphoid organs (TLO) as a potential marker of relapse in this condition
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|a Journal Article
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|a Review
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|a IgG4 subclass
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|a IgG4-related disease
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|a Innate immune system
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|a Plasmablasts
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| 650 |
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|a Rituximab
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|a T-follicular helper cells
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|a Tertiary lymphoid organs
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| 650 |
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|a Immunoglobulin G
|2 NLM
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| 700 |
1 |
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|a Pozdzik, Agnieszka
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 198(2019) vom: 01. Jan., Seite 1-10
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|g volume:198
|g year:2019
|g day:01
|g month:01
|g pages:1-10
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|u http://dx.doi.org/10.1016/j.clim.2018.11.004
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