Signaling lymphocyte activation molecule family in systemic lupus erythematosus

Copyright © 2018 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 204(2019) vom: 01. Juli, Seite 57-63
1. Verfasser: Comte, Denis (VerfasserIn)
Weitere Verfasser: Karampetsou, Maria P, Humbel, Morgane, Tsokos, George C
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Review Signaling Lymphocytic Activation Molecule Family
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520 |a Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by a breakdown in immune tolerance leading to the development of auto-reactive lymphocytes and autoantibodies. Recent findings have provided new insight on the role of the signaling lymphocytic activation molecule family (SLAMF) receptors, a group of nine co-regulatory molecules involved in the activation of hematopoietic cells, and their downstream protein SLAM-associated protein (SAP), into the pathogenesis of SLE. This review summarizes the current knowledge on SLAMF in human SLE immunopathogenesis, and the importance of SLAMF molecules as new therapeutic targets 
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700 1 |a Tsokos, George C  |e verfasserin  |4 aut 
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