A multicenter study of reference intervals for 15 laboratory parameters in Chinese children

A multicenter study of reference intervals for 15 laboratory parameters in Chinese children

Objective: To establish comprehensive laboratory reference intervals for Chinese children. Methods: This was a cross-sectional multicenter study. From June 2013 to December 2014, eligible healthy children aged from 6-month to 17-year were enrolled from 20 medical centers with informed consent. They...

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Veröffentlicht in:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 56(2018), 11 vom: 02. Nov., Seite 835-845
1. Verfasser: Zhong, X H (VerfasserIn)
Weitere Verfasser: Ding, J, Zhou, J H, Yu, Z H, Sun, S Z, Bao, Y, Mao, J H, Yu, L, Li, Z H, Han, Z M, Song, H M, Jiang, X Y, Liu, Y L, Zhang, B L, Xia, Z K, Jin, C H, Zhu, G H, Wang, M, Feng, S P, Shen, Y, Huang, S M, Ma, Q S, Li, H X, Wang, X J, Ichihara, K, Yao, C, Dong, C Y
Format: Online-Aufsatz
Sprache:Chinese
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Zhonghua er ke za zhi = Chinese journal of pediatrics
Schlagworte:Journal Article Multicenter Study Child Multicenter study Reference interval Estradiol 4TI98Z838E Luteinizing Hormone 9002-67-9 Follicle Stimulating Hormone 9002-68-0
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520 |a Objective: To establish comprehensive laboratory reference intervals for Chinese children. Methods: This was a cross-sectional multicenter study. From June 2013 to December 2014, eligible healthy children aged from 6-month to 17-year were enrolled from 20 medical centers with informed consent. They were assessed by physical examination, questionnaire survey and abdominal ultrasound for eligibility. Fasting blood samples were collected and delivered to central laboratory. Measurements of 15 clinical laboratory parameters were performed, including estradiol (E2), testosterone(T), luteinizing hormone(LH), follicle-stimulating hormone(FSH), alanine transaminase(ALT), serum creatinine(Scr), cystatin C, immunoglobulin A(IgA), immunoglobulin G(IgG), immunoglobulin M(IgM), complement (C3, C4), alkaline phosphatase(ALP), uric acid(UA) and creatine kinase(CK). Reference intervals were established according to central 95% confidence intervals for reference population, stratified by age and sex. Results: In total, 2 259 children were enrolled. Finally, 1 648 children were eligible for this study, including 830 boys and 818 girls, at a mean age of 7.4 years. Age- and sex- specific reference intervals have been established for the parameters. Reference intervals of sex hormones increased gradually with age. Concentrations of ALT, cystatin C, ALP and CK were higher in children under 2 years old. Serum levels of sex hormones, creatinine, immunoglobin, CK, ALP and urea increased rapidly in adolescence, with significant sex difference. In addition, reference intervals were variable depending on assay methods. Concentrations of ALT detected by reagents with pyridoxal 5'-phosphate(PLP) were higher than those detected by reagents without PLP. Compared with enzymatic method, Jaffe assay always got higher results of serum creatinine, especially in children younger than 9 years old. Conclusion: This study established age- and sex- specific reference intervals, for 15 clinical laboratory parameters based on defined healthy children 
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650 4 |a Multicenter study 
650 4 |a Reference interval 
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700 1 |a Ding, J  |e verfasserin  |4 aut 
700 1 |a Zhou, J H  |e verfasserin  |4 aut 
700 1 |a Yu, Z H  |e verfasserin  |4 aut 
700 1 |a Sun, S Z  |e verfasserin  |4 aut 
700 1 |a Bao, Y  |e verfasserin  |4 aut 
700 1 |a Mao, J H  |e verfasserin  |4 aut 
700 1 |a Yu, L  |e verfasserin  |4 aut 
700 1 |a Li, Z H  |e verfasserin  |4 aut 
700 1 |a Han, Z M  |e verfasserin  |4 aut 
700 1 |a Song, H M  |e verfasserin  |4 aut 
700 1 |a Jiang, X Y  |e verfasserin  |4 aut 
700 1 |a Liu, Y L  |e verfasserin  |4 aut 
700 1 |a Zhang, B L  |e verfasserin  |4 aut 
700 1 |a Xia, Z K  |e verfasserin  |4 aut 
700 1 |a Jin, C H  |e verfasserin  |4 aut 
700 1 |a Zhu, G H  |e verfasserin  |4 aut 
700 1 |a Wang, M  |e verfasserin  |4 aut 
700 1 |a Feng, S P  |e verfasserin  |4 aut 
700 1 |a Shen, Y  |e verfasserin  |4 aut 
700 1 |a Huang, S M  |e verfasserin  |4 aut 
700 1 |a Ma, Q S  |e verfasserin  |4 aut 
700 1 |a Li, H X  |e verfasserin  |4 aut 
700 1 |a Wang, X J  |e verfasserin  |4 aut 
700 1 |a Ichihara, K  |e verfasserin  |4 aut 
700 1 |a Yao, C  |e verfasserin  |4 aut 
700 1 |a Dong, C Y  |e verfasserin  |4 aut 
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