Hydrophobic Modification of Carboxyl-Terminated Polyamidoamine Dendrimer Surface Creates a Potent Inhibitor of Amyloid-β Fibrillation

Amyloid β-peptide (Aβ) fibrillogenesis is a major hallmark of Alzheimer's disease (AD); inhibition of Aβ fibrillation is thus considered as a promising strategy for AD prevention and treatment. Our group has previously proposed the hydrophobic binding-electrostatic repulsion (HyBER) hypothesis,...

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Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 34(2018), 47 vom: 27. Nov., Seite 14419-14427
1. Verfasser:	Wang, Ziyuan (VerfasserIn)
Weitere Verfasser:	Dong, Xiaoyan, Sun, Yan
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2018
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Amyloid beta-Peptides Dendrimers PAMAM Starburst Peptide Fragments Protein Aggregates amyloid beta-protein (1-42)