Nanoparticle-Laden Macrophages for Tumor-Tropic Drug Delivery

Nanoparticle-Laden Macrophages for Tumor-Tropic Drug Delivery

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 30(2018), 50 vom: 15. Dez., Seite e1805557
1. Verfasser: Zhang, Weizhong (VerfasserIn)
Weitere Verfasser: Wang, Mengzhe, Tang, Wei, Wen, Ru, Zhou, Shiyi, Lee, Chaebin, Wang, Hui, Jiang, Wen, Delahunty, Ian Michael, Zhen, Zipeng, Chen, Hongmin, Chapman, Matthew, Wu, Zhanhong, Howerth, Elizabeth W, Cai, Houjian, Li, Zibo, Xie, Jin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article cancer cell-mediated drug delivery doxorubicin glioblastoma macrophages nanoparticles Drug Carriers Silicon Dioxide 7631-86-9 mehr... Doxorubicin 80168379AG
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100 1 |a Zhang, Weizhong  |e verfasserin  |4 aut 
245 1 0 |a Nanoparticle-Laden Macrophages for Tumor-Tropic Drug Delivery 
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500 |a Date Completed 14.03.2019 
500 |a Date Revised 16.07.2024 
500 |a published: Print-Electronic 
500 |a ErratumIn: Adv Mater. 2022 Feb;34(6):e2109925. doi: 10.1002/adma.202109925. - PMID 35141954 
500 |a Citation Status MEDLINE 
520 |a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 
520 |a Macrophages hold great potential in cancer drug delivery because they can sense chemotactic cues and home to tumors with high efficiency. However, it remains a challenge to load large amounts of therapeutics into macrophages without compromising cell functions. This study reports a silica-based drug nanocapsule approach to solve this issue. The nanocapsule consists of a drug-silica complex filling and a solid silica sheath, and it is designed to minimally release drug molecules in the early hours of cell entry. While taken up by macrophages at high rates, the nanocapsules minimally affect cell migration in the first 6-12 h, buying time for macrophages to home to tumors and release drugs in situ. In particular, it is shown that doxorubicin (Dox) as a representative drug can be loaded into macrophages up to 16.6 pg per cell using this approach. When tested in a U87MG xenograft model, intravenously (i.v.) injected Dox-laden macrophages show comparable tumor accumulation as untreated macrophages. Therapy leads to efficient tumor growth suppression, while causing little systematic toxicity. This study suggests a new cell platform for selective drug delivery, which can be readily extended to the treatment of other types of diseases 
650 4 |a Journal Article 
650 4 |a cancer 
650 4 |a cell-mediated drug delivery 
650 4 |a doxorubicin 
650 4 |a glioblastoma 
650 4 |a macrophages 
650 4 |a nanoparticles 
650 7 |a Drug Carriers  |2 NLM 
650 7 |a Silicon Dioxide  |2 NLM 
650 7 |a 7631-86-9  |2 NLM 
650 7 |a Doxorubicin  |2 NLM 
650 7 |a 80168379AG  |2 NLM 
700 1 |a Wang, Mengzhe  |e verfasserin  |4 aut 
700 1 |a Tang, Wei  |e verfasserin  |4 aut 
700 1 |a Wen, Ru  |e verfasserin  |4 aut 
700 1 |a Zhou, Shiyi  |e verfasserin  |4 aut 
700 1 |a Lee, Chaebin  |e verfasserin  |4 aut 
700 1 |a Wang, Hui  |e verfasserin  |4 aut 
700 1 |a Jiang, Wen  |e verfasserin  |4 aut 
700 1 |a Delahunty, Ian Michael  |e verfasserin  |4 aut 
700 1 |a Zhen, Zipeng  |e verfasserin  |4 aut 
700 1 |a Chen, Hongmin  |e verfasserin  |4 aut 
700 1 |a Chapman, Matthew  |e verfasserin  |4 aut 
700 1 |a Wu, Zhanhong  |e verfasserin  |4 aut 
700 1 |a Howerth, Elizabeth W  |e verfasserin  |4 aut 
700 1 |a Cai, Houjian  |e verfasserin  |4 aut 
700 1 |a Li, Zibo  |e verfasserin  |4 aut 
700 1 |a Xie, Jin  |e verfasserin  |4 aut 
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773 1 8 |g volume:30  |g year:2018  |g number:50  |g day:15  |g month:12  |g pages:e1805557 
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