CYP81A P450s are involved in concomitant cross-resistance to acetolactate synthase and acetyl-CoA carboxylase herbicides in Echinochloa phyllopogon

CYP81A P450s are involved in concomitant cross-resistance to acetolactate synthase and acetyl-CoA carboxylase herbicides in Echinochloa phyllopogon

© 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 221(2019), 4 vom: 22. März, Seite 2112-2122
1. Verfasser: Iwakami, Satoshi (VerfasserIn)
Weitere Verfasser: Kamidate, Yoshitaka, Yamaguchi, Takuya, Ishizaka, Masumi, Endo, Masaki, Suda, Hiroe, Nagai, Kiichi, Sunohara, Yukari, Toki, Seiichi, Uchino, Akira, Tominaga, Tohru, Matsumoto, Hiroshi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Echinochloa phyllopogon cross-resistance cytochrome P450 evolution herbicide metabolism herbicide resistance late watergrass polyploid mehr... Enzyme Inhibitors Herbicides Cytochrome P-450 Enzyme System 9035-51-2 Acetolactate Synthase EC 2.2.1.6 Acetyl-CoA Carboxylase EC 6.4.1.2
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520 |a Californian populations of Echinochloa phyllopogon have evolved multiple-herbicide resistance (MHR), posing a threat to rice production in California. Previously, we identified two CYP81A cytochrome P450 genes whose overexpression is associated with resistance to acetolactate synthase (ALS) inhibitors from two chemical groups. Resistance mechanisms to other herbicides remain unknown. We analyzed the sensitivity of an MHR line to acetyl-CoA carboxylase (ACCase) inhibitors from three chemical groups, followed by an analysis of herbicide metabolism and segregation of resistance of the progenies in sensitive (S) and MHR lines. ACCase herbicide metabolizing function was investigated in the two previously identified P450s. MHR plants exhibited resistance to all the ACCase inhibitors by enhanced herbicide metabolism. Resistance to the ACCase inhibitors segregated in a 3 : 1 ratio in the F2 generation and completely co-segregated with ALS inhibitor resistance in F6 lines. Expression of the respective P450 genes conferred resistance to the three herbicides in rice, which is in line with the detection of hydroxylated herbicide metabolites in vivo in transformed yeast. CYP81As are super P450s that metabolize multiple herbicides from five chemical classes, and concurrent overexpression of the P450s induces metabolism-based resistance to the three ACCase inhibitors in MHR E. phyllopogon, as it does to ALS inhibitors 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Echinochloa phyllopogon 
650 4 |a cross-resistance 
650 4 |a cytochrome P450 
650 4 |a evolution 
650 4 |a herbicide metabolism 
650 4 |a herbicide resistance 
650 4 |a late watergrass 
650 4 |a polyploid 
650 7 |a Enzyme Inhibitors  |2 NLM 
650 7 |a Herbicides  |2 NLM 
650 7 |a Cytochrome P-450 Enzyme System  |2 NLM 
650 7 |a 9035-51-2  |2 NLM 
650 7 |a Acetolactate Synthase  |2 NLM 
650 7 |a EC 2.2.1.6  |2 NLM 
650 7 |a Acetyl-CoA Carboxylase  |2 NLM 
650 7 |a EC 6.4.1.2  |2 NLM 
700 1 |a Kamidate, Yoshitaka  |e verfasserin  |4 aut 
700 1 |a Yamaguchi, Takuya  |e verfasserin  |4 aut 
700 1 |a Ishizaka, Masumi  |e verfasserin  |4 aut 
700 1 |a Endo, Masaki  |e verfasserin  |4 aut 
700 1 |a Suda, Hiroe  |e verfasserin  |4 aut 
700 1 |a Nagai, Kiichi  |e verfasserin  |4 aut 
700 1 |a Sunohara, Yukari  |e verfasserin  |4 aut 
700 1 |a Toki, Seiichi  |e verfasserin  |4 aut 
700 1 |a Uchino, Akira  |e verfasserin  |4 aut 
700 1 |a Tominaga, Tohru  |e verfasserin  |4 aut 
700 1 |a Matsumoto, Hiroshi  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t The New phytologist  |d 1979  |g 221(2019), 4 vom: 22. März, Seite 2112-2122  |w (DE-627)NLM09818248X  |x 1469-8137  |7 nnns 
773 1 8 |g volume:221  |g year:2019  |g number:4  |g day:22  |g month:03  |g pages:2112-2122 
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