Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles

Controlling lateral interactions between lipid molecules in a bilayer membrane to guide membrane organization and domain formation is a key factor for studying and emulating membrane functionality in synthetic biological systems. Here, we demonstrate an approach to reversibly control lipid organizat...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 34(2018), 44 vom: 06. Nov., Seite 13368-13374
1. Verfasser: Urban, Patrick (VerfasserIn)
Weitere Verfasser: Pritzl, Stefanie D, Konrad, David B, Frank, James A, Pernpeintner, Carla, Roeske, Christian R, Trauner, Dirk, Lohmüller, Theobald
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Video-Audio Media Azo Compounds Lipid Bilayers Phosphatidylcholines Unilamellar Liposomes 1,2-diphytanoylphosphatidylcholine 32448-32-1
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520 |a Controlling lateral interactions between lipid molecules in a bilayer membrane to guide membrane organization and domain formation is a key factor for studying and emulating membrane functionality in synthetic biological systems. Here, we demonstrate an approach to reversibly control lipid organization, domain formation, and membrane stiffness of phospholipid bilayer membranes using the photoswitchable phospholipid azo-PC. azo-PC contains an azobenzene group in the sn2 acyl chain that undergoes reversible photoisomerization on illumination with UV-A and visible light. We demonstrate that the concentration of the photolipid molecules and also the assembly and disassembly of photolipids into lipid domains can be monitored by UV-vis spectroscopy because of a blue shift induced by photolipid aggregation 
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650 4 |a Research Support, Non-U.S. Gov't 
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700 1 |a Pritzl, Stefanie D  |e verfasserin  |4 aut 
700 1 |a Konrad, David B  |e verfasserin  |4 aut 
700 1 |a Frank, James A  |e verfasserin  |4 aut 
700 1 |a Pernpeintner, Carla  |e verfasserin  |4 aut 
700 1 |a Roeske, Christian R  |e verfasserin  |4 aut 
700 1 |a Trauner, Dirk  |e verfasserin  |4 aut 
700 1 |a Lohmüller, Theobald  |e verfasserin  |4 aut 
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