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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/ery365
|2 doi
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|a pubmed24n0966.xml
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|a (NLM)30346598
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Jiang, Wen
|e verfasserin
|4 aut
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| 245 |
1 |
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|a jaw-1D
|b a gain-of-function mutation responsive to paramutation-like induction of epigenetic silencing
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 11.02.2020
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|a Date Revised 09.03.2020
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|a published: Print
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|a Citation Status MEDLINE
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|a The Arabidopsis thaliana gain-of-function T-DNA insertion mutant jaw-1D produces miR319A, a microRNA that represses genes encoding CIN-like TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTORs (TCPs), a family of transcription factors that play key roles in leaf morphogenesis. In this study, we show that jaw-1D is responsive to paramutation-like epigenetic silencing. A genetic cross of jaw-1D with the polycomb gene mutant curly leaf-29 (clf-29) leads to attenuation of the jaw-1D mutant plant phenotype. This induced mutation, jaw-1D*, was associated with down-regulation of miR319A, was heritable independently from clf-29, and displayed paramutation-like non-Mendelian inheritance. Down-regulation of miR319A in jaw-1D* was linked to elevated levels of histone H3 lysine 9 dimethylation and DNA methylation at the CaMV35S enhancer located within the activation-tagging T-DNA of the jaw-1D locus. Examination of 21 independent T-DNA insertion mutant lines revealed that 11 could attenuate the jaw-1D mutant phenotype in a similar way to the paramutation induced by clf-29. These paramutagenic mutant lines shared the common feature that their T-DNA insertion was present as multi-copy tandem repeats and contained high levels of CG and CHG methylation. Our results provide important insights into paramutation-like epigenetic silencing, and caution against the use of jaw-1D in genetic interaction studies
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a MIRN319 microRNA, Arabidopsis
|2 NLM
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| 650 |
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|a MicroRNAs
|2 NLM
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| 700 |
1 |
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|a Li, Zhongfei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, Xiaozhen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Binglian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Wen-Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Aiwu
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 70(2019), 2 vom: 07. Jan., Seite 459-468
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:70
|g year:2019
|g number:2
|g day:07
|g month:01
|g pages:459-468
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|u http://dx.doi.org/10.1093/jxb/ery365
|3 Volltext
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|d 70
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|h 459-468
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