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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201802444
|2 doi
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|a eng
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|a Yang, Ming-Da
|e verfasserin
|4 aut
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|a Magnetic Interaction of Multifunctional Core-Shell Nanoparticles for Highly Effective Theranostics
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|c 2018
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|a Text
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|a ƒaComputermedien
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|a Date Completed 12.12.2018
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|a Date Revised 30.07.2024
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a The controlled size and surface treatment of magnetic nanoparticles (NPs) make one-stage combination feasible for enhanced magnetic resonance imaging (MRI) contrast and effective hyperthermia. However, superparamagnetic behavior, essential for avoiding the aggregation of magnetic NPs, substantially limits their performance. Here, a superparamagnetic core-shell structure is developed, which promotes the formation of vortex-like intraparticle magnetization structures in the remanent state, leading to reduced dipolar interactions between two neighboring NPs, while during an MRI scan, the presence of a DC magnetic field induces the formation of NP chains, introducing increased local inhomogeneous dipole fields that enhance relaxivity. The core-shell NPs also reveal an augmented anisotropy, due to exchange coupling to the high anisotropy core, which enhances the specific absorption rate. This in vivo tumor study reveals that the tumor cells can be clearly diagnosed during an MRI scan and the tumor size is substantially reduced through hyperthermia therapy by using the same FePtiron oxide nanoparticles, realizing the concept of theranostics
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|a Journal Article
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|a core-shell
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|a hyperthermia
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|a magnetic interaction
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|a magnetic resonance image
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|a theranostics
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1 |
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|a Ho, Chien-Hsin
|e verfasserin
|4 aut
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1 |
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|a Ruta, Sergiu
|e verfasserin
|4 aut
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|a Chantrell, Roy
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|a Krycka, Kathryn
|e verfasserin
|4 aut
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|a Hovorka, Ondrej
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|4 aut
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|a Chen, Fu-Rong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lai, Ping-Shan
|e verfasserin
|4 aut
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| 700 |
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|a Lai, Chih-Huang
|e verfasserin
|4 aut
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| 773 |
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 30(2018), 50 vom: 23. Dez., Seite e1802444
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