Podocyte foot process width is a prediction marker for complete renal response at 6 and 12 months after induction therapy in lupus nephritis

Podocyte foot process width is a prediction marker for complete renal response at 6 and 12 months after induction therapy in lupus nephritis

Copyright © 2018 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 197(2018) vom: 01. Dez., Seite 161-168
1. Verfasser: Ichinose, Kunihiro (VerfasserIn)
Weitere Verfasser: Kitamura, Mineaki, Sato, Shuntaro, Fujikawa, Keita, Horai, Yoshiro, Matsuoka, Naoki, Tsuboi, Masahiko, Nonaka, Fumiaki, Shimizu, Toshimasa, Fukui, Shoichi, Umeda, Masataka, Koga, Tomohiro, Kawashiri, Shin-Ya, Iwamoto, Naoki, Igawa, Takashi, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nishino, Tomoya, Kawakami, Atsushi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Complete renal responses Foot process width Lupus nephritis Podocyte Glucocorticoids Immunosuppressive Agents Cyclosporine 83HN0GTJ6D mehr... Cyclophosphamide 8N3DW7272P Prednisolone 9PHQ9Y1OLM Creatinine AYI8EX34EU Mycophenolic Acid HU9DX48N0T Tacrolimus WM0HAQ4WNM Methylprednisolone X4W7ZR7023
Beschreibung
Zusammenfassung:Copyright © 2018 Elsevier Inc. All rights reserved.
Morphological change that includes diffuse effacement of podocyte foot processes is correlated with proteinuria in patients with lupus nephritis (LN). We collected the data of clinico-pathological parameters and assessed foot process width (FPW) as an index of podocyte effacement in 73 patients with LN who had undergone renal biopsy. The multivariate analysis revealed that female gender (OR: 5.288; 95%CI: 1.197-37.29; p = .0267) and FPW (OR = 0.999, 95%CI = 0.997-0.999, p = .0150) were significantly predictive of a complete renal response (CR) at 6 months, while lymphocyte counts (OR = 1.002; 95%CI = 1.001-1.003, p = .0028) and FPW (OR = 0.998, 95%CI = 0.996-0.999, p = .0027) were significantly predictive of CR at 12 months. The cut-off point determined by the Classification and Regression Trees algorithm showed that FPW <908.3 nm provides the best performance for predicting patients who achieve CR at 12 months. A smaller FPW appears to be a predictive factor for CR at 6 and 12 months after induction therapy
Beschreibung:Date Completed 07.10.2019
Date Revised 07.10.2019
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2018.10.002