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20250224053303.0 |
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cr uuu---uuuuu |
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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2018.10.001
|2 doi
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|a pubmed25n0964.xml
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|a (DE-627)NLM289319021
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|a (NLM)30296590
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|a (PII)S1521-6616(18)30388-7
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Xu, Changliang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Fra-2 is a novel candidate drug target expressed in the podocytes of lupus nephritis
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|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 07.10.2019
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|a Date Revised 04.12.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2018 Elsevier Inc. All rights reserved.
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|a Lupus nephritis (LN) is a common and devastating complication caused by systemic lupus erythematosus. In this study, we evaluated the expression and mechanism of Fos-related antigen 2 (Fra-2) in LN. The results showed that Fra-2 was significantly increased in kidney biopsies of LN patients compared with healthy controls and other kidney disease in glomerular podocytes. The MRL/lpr mouse strain is a murine model of lupus, and it was used to study the mechanisms of Fra-2 in LN. The results showed that Fra-2 was expressed in the glomerular podocytes. We investigated the effects of inflammatory stimuli on Fra-2 protein expression in the glomerular podocytes, and found that interferon gamma was most effective at increasing Fra-2 protein expression. Knockdown of Fra-2 using siRNA enhanced the protein expression of nephrin. Therefore, Fra-2 may be a specific drug target for podocyte injury in LN
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4 |
|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Fra 2
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| 650 |
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4 |
|a Kidney injury
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| 650 |
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4 |
|a Lupus nephritis
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| 650 |
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4 |
|a MRL/lpr mice
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| 650 |
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4 |
|a Podocytes
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| 650 |
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7 |
|a Antiviral Agents
|2 NLM
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| 650 |
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|a FOSL2 protein, human
|2 NLM
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| 650 |
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|a Fos-Related Antigen-2
|2 NLM
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| 650 |
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7 |
|a Fosl2 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Membrane Proteins
|2 NLM
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| 650 |
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7 |
|a nephrin
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Miao, Yunjie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pi, Qingmeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Shouchao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Furong
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 197(2018) vom: 01. Dez., Seite 179-185
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
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|g volume:197
|g year:2018
|g day:01
|g month:12
|g pages:179-185
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2018.10.001
|3 Volltext
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|d 197
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