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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.12900
|2 doi
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|a eng
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| 100 |
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|a Lukhwareni, Refilwe
|e verfasserin
|4 aut
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| 245 |
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|a Histology and ultrastructure of hepatic nodular alterations in Clarias gariepinus (Burchell, 1822)
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|c 2018
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|a Text
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|a ƒaComputermedien
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|a Date Completed 17.12.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 John Wiley & Sons Ltd.
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|a This study aimed to assess the macroscopic appearance, histology and ultrastructure of liver nodular alterations in sharptooth catfish Clarias gariepinus (Burchell, 1822) from a hyper-eutrophic freshwater impoundment. The livers of 25 fish were sampled for microscopy analyses, otoliths were collected for age estimation, and the hepatosomatic index (HSI) was calculated. The light microscopic analysis of the nodular tissue revealed hepatocellular and nuclear pleomorphism, pyknotic nuclei, variation in cytoplasmic appearance and focal areas of cellular alterations (FCAs). An increase in the size and number of melano-macrophage centres, intracellular deposits, steatosis and giant cells was also identified. The ultrastructural alterations identified included cell membrane disruption, irregular shaped nuclei with augmentation of the nucleolus and deformed nuclear envelopes. In addition, we found dilation, proliferation, fragmentation and vesiculation of the cisternae of the rough endoplasmic reticulum (RER). Furthermore, there was an increase in degenerative mitochondria (transparent matrix), swelling of mitochondria and proliferation of both peroxisomes and lysosomes. The histological and ultrastructural alterations identified did not explain the variation in macroscopic colour of the nodules. We did not find a strong positive correlation between age and HSI; however, the oldest fish (18 years) did present the most nodules
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|a Journal Article
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|a Roodeplaat Dam
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|a age
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|a hepatosomatic index
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|a histopathology
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|a liver
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|a van Dyk, Cobus
|e verfasserin
|4 aut
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|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 41(2018), 12 vom: 24. Dez., Seite 1859-1870
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|x 1365-2761
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|g volume:41
|g year:2018
|g number:12
|g day:24
|g month:12
|g pages:1859-1870
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| 856 |
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|u http://dx.doi.org/10.1111/jfd.12900
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