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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201803591
|2 doi
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|a pubmed24n0963.xml
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|a (DE-627)NLM289132258
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|a (NLM)30277606
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Kang, Heemin
|e verfasserin
|4 aut
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| 245 |
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|a An In Situ Reversible Heterodimeric Nanoswitch Controlled by Metal-Ion-Ligand Coordination Regulates the Mechanosensing and Differentiation of Stem Cells
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 04.02.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a In situ and cytocompatible nanoswitching by external stimuli is highly appealing for reversibly regulating cellular adhesion and functions in vivo. Here, a heterodimeric nanoswitch is designed to facilitate in situ switchable and combinatorial presentation of integrin-binding cell-adhesive moieties, such as Mg2+ and Arg-Gly-Asp (RGD) ligand in nanostructures. In situ reversible nanoswitching is controlled by convertible coordination between bioactive Mg2+ and bisphosphonate (BP) ligand. A BP-coated gold-nanoparticle monomer (BP-AuNP) on a substrate is prepared to allow in situ assembly of cell-adhesive Mg2+ -active Mg-BP nanoparticles (NPs) on a BP-AuNP surface via Mg2+ -BP coordination, yielding heterodimeric nanostructures (switching "ON"). Ethylenediaminetetraacetic acid (EDTA)-based Mg2+ chelation allows in situ disassembly of Mg2+ -BP NP, reverting to Mg2+ -free monomer (switching "OFF"). This in situ reversible nanoswitching on and off of cell-adhesive Mg2+ presentation allows reversible cell adhesion and release in vivo, respectively, and spatiotemporally controls cyclic cell adhesion. In situ heterodimeric assembly of dual RGD ligand- and Mg2+ -active RGD-BP-Mg2+ NP (switching "Dual ON") further tunes and promotes focal adhesion, spreading, and differentiation of stem cells. The modular nature of this in situ nanoswitch can accommodate various bioactive nanostructures via metal-ion-ligand coordination to regulate diverse cellular functions in vivo in reversible and compatible manner
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|a Journal Article
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|a in situ nanoswitches
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|a in vivo cell adhesion
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|a in vivo cell release
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|a metal-ion-ligand coordination
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4 |
|a reversible heterodimers
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|a Ligands
|2 NLM
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|a Oligopeptides
|2 NLM
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|a arginyl-glycyl-aspartic acid
|2 NLM
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|a 78VO7F77PN
|2 NLM
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| 650 |
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|a Magnesium
|2 NLM
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| 650 |
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|a I38ZP9992A
|2 NLM
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| 700 |
1 |
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|a Zhang, Kunyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jung, Hee Joon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Boguang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xiaoyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pan, Qi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Rui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Xiayi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Gang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dravid, Vinayak P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bian, Liming
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 44 vom: 17. Nov., Seite e1803591
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:30
|g year:2018
|g number:44
|g day:17
|g month:11
|g pages:e1803591
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201803591
|3 Volltext
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|a AR
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|d 30
|j 2018
|e 44
|b 17
|c 11
|h e1803591
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