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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201804046
|2 doi
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|a pubmed24n0963.xml
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|a (DE-627)NLM28896425X
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|a (NLM)30260520
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Du, Zhen
|e verfasserin
|4 aut
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| 245 |
1 |
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|a X-Ray-Controlled Generation of Peroxynitrite Based on Nanosized LiLuF4 :Ce3+ Scintillators and their Applications for Radiosensitization
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 01.02.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Peroxynitrite (ONOO- ), the reaction product derived from nitric oxide (NO) and superoxide (O2 -• ), is a potent oxidizing and nitrating agent that modulates complex biological processes and promotes cell death. Therefore, it can be expected that the overproduction of ONOO- in tumors can be an efficient approach in cancer therapy. Herein, a multifunctional X-ray-controlled ONOO- generation platform based on scintillating nanoparticles (SCNPs) and UV-responsive NO donors Roussin's black salt is reported, and consequently the mechanism of their application in enhanced therapeutic efficacy of radiotherapy is illustrated. Attributed to the radioluminescence and high X-ray-absorbing property of SCNPs, the nanocomposite can produce NO and O2 -• simultaneously when excited by X-ray irradiation. Such simultaneous release of NO and O2 -• ensures the efficient X-ray-controlled generation of ONOO- in tumors. Meanwhile, the application of X-rays as the excitation source can achieve better penetration depth and induce radiotherapy in this nanotherapeutic platform. It is found that the X-ray-controlled ONOO- -generation platform can efficiently improve the radiotherapy efficiency via directly damaging DNA, downregulating the expression of the DNA-repair enzyme, and overcoming the hypoxia-associated resistance in radiotherapy. Therefore, this SCNP-based platform may provide a new combinatorial strategy of ONOO- and radiotherapy to improve cancer treatment
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|a Journal Article
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|a DNA-repair enzymes
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|a nitric oxide
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|a peroxynitrite
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|a radiosensitization
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|a scintillators
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|a Iron Compounds
|2 NLM
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|a Lithium Compounds
|2 NLM
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|a Nitroso Compounds
|2 NLM
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| 650 |
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|a Radiation-Sensitizing Agents
|2 NLM
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| 650 |
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|a Peroxynitrous Acid
|2 NLM
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| 650 |
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|a 14691-52-2
|2 NLM
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| 650 |
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|a Roussin's Black Salt
|2 NLM
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| 650 |
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|a 37305-51-4
|2 NLM
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| 700 |
1 |
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|a Zhang, Xiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guo, Zhao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Jiani
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Xinghua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Shuang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Du, Jiangfeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gu, Zhanjun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Yuliang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 43 vom: 05. Okt., Seite e1804046
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:30
|g year:2018
|g number:43
|g day:05
|g month:10
|g pages:e1804046
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201804046
|3 Volltext
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|d 30
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