Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection

Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 30(2018), 45 vom: 15. Nov., Seite e1805018
1. Verfasser: Wu, Jindao (VerfasserIn)
Weitere Verfasser: Zheng, Zhen, Chong, Yuanyuan, Li, Xiangcheng, Pu, Liyong, Tang, Qiyun, Yang, Liu, Wang, Xuehao, Wang, Fuqiang, Liang, Gaolin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article hydrogels immune responsive release organ transplant rejection protein tyrosine kinase tacrolimus Hydrogels Immunosuppressive Agents Viscoelastic Substances Protein-Tyrosine Kinases mehr... EC 2.7.10.1 Tacrolimus WM0HAQ4WNM
Beschreibung
Zusammenfassung:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Transplant rejection is the key problem in organ transplantation and, in clinic, immunosuppressive agents such as tacrolimus are directly administered to the recipients after surgery for T-cell inhibition. However, direct administration of tacrolimus may bring severe side effects to the recipients. Herein, by rational design of two hydrogelators NapPhePheGluTyrOH (1) and Nap d-Phe dPheGluTyrOH (2), a facile method of immune responsive release of tacrolimus is developed from their hydrogels to overcome organ transplantation rejection. Upon incubation with protein tyrosine kinase, which is activated in T cells after organ transplantation, the tacrolimus-encapsulating Gel 1 or Gel 2 is disassembled to release tacrolimus. Cell experiments show that both Gel 1 and Gel 2 have better inhibition effect on the activated T cells than free drug tacrolimus. Liver transplantation experiments indicate that, after 7 days of treatment of same dose tacrolimus, the recipient rats in the Gel 2 group show significantly extended median survival time of 22 days while the recipients treated with conventional tacrolimus medication have a median survival time of 13 days. It is expected herein that this "smart" facile method of immune responsive release of tacrolimus can be applied to overcome organ transplantation rejection in clinic in the near future
Beschreibung:Date Completed 18.01.2019
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201805018