|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM288770803 |
| 003 |
DE-627 |
| 005 |
20240620232126.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2018 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2018.09.008
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1446.xml
|
| 035 |
|
|
|a (DE-627)NLM288770803
|
| 035 |
|
|
|a (NLM)30240602
|
| 035 |
|
|
|a (PII)S1521-6616(18)30294-8
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Shulzhenko, Natalia
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont
|
| 264 |
|
1 |
|c 2018
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 07.10.2019
|
| 500 |
|
|
|a Date Revised 20.06.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2018 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Common variable immunodeficiency (CVID), the most common symptomatic primary antibody deficiency, is accompanied in some patients by a duodenal inflammation and malabsorption syndrome known as CVID enteropathy (E-CVID).The goal of this study was to investigate the immunological abnormalities in CVID patients that lead to enteropathy as well as the contribution of intestinal microbiota to this process.We found that, in contrast to noE-CVID patients (without enteropathy), E-CVID patients have exceedingly low levels of IgA in duodenal tissues. In addition, using transkingdom network analysis of the duodenal microbiome, we identified Acinetobacter baumannii as a candidate pathobiont in E-CVID. Finally, we found that E-CVID patients exhibit a pronounced activation of immune genes and down-regulation of epithelial lipid metabolism genes. We conclude that in the virtual absence of mucosal IgA, pathobionts such as A. baumannii, may induce inflammation that re-directs intestinal molecular pathways from lipid metabolism to immune processes responsible for enteropathy
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, N.I.H., Extramural
|
| 650 |
|
4 |
|a Research Support, N.I.H., Intramural
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Immunoglobulin A
|2 NLM
|
| 650 |
|
7 |
|a RNA, Bacterial
|2 NLM
|
| 650 |
|
7 |
|a RNA, Ribosomal, 16S
|2 NLM
|
| 650 |
|
7 |
|a Interferons
|2 NLM
|
| 650 |
|
7 |
|a 9008-11-1
|2 NLM
|
| 700 |
1 |
|
|a Dong, Xiaoxi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Vyshenska, Dariia
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Greer, Renee L
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Gurung, Manoj
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Vasquez-Perez, Stephany
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Peremyslova, Ekaterina
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sosnovtsev, Stanislav
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Quezado, Martha
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yao, Michael
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Montgomery-Recht, Kim
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Strober, Warren
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Fuss, Ivan J
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Morgun, Andrey
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 197(2018) vom: 01. Dez., Seite 139-153
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:197
|g year:2018
|g day:01
|g month:12
|g pages:139-153
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2018.09.008
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 197
|j 2018
|b 01
|c 12
|h 139-153
|