Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to RADICAL-INDUCED CELL DEATH1

Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to RADICAL-INDUCED CELL DEATH1

© 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 220(2018), 1 vom: 01. Okt., Seite 232-248
1. Verfasser: Wirthmueller, Lennart (VerfasserIn)
Weitere Verfasser: Asai, Shuta, Rallapalli, Ghanasyam, Sklenar, Jan, Fabro, Georgina, Kim, Dae Sung, Lintermann, Ruth, Jaspers, Pinja, Wrzaczek, Michael, Kangasjärvi, Jaakko, MacLean, Daniel, Menke, Frank L H, Banfield, Mark J, Jones, Jonathan D G
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Arabidopsis thaliana Hyaloperonospora arabidopsidis RADICAL-INDUCED CELL DEATH1 oomycete pathogen pathogen effector plant innate immunity salicylic acid (SA) Arabidopsis Proteins mehr... NPR1 protein, Arabidopsis Nuclear Proteins Proteins RCD1 protein, Arabidopsis ADP Ribose Transferases EC 2.4.2.- Salicylic Acid O414PZ4LPZ
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100 1 |a Wirthmueller, Lennart  |e verfasserin  |4 aut 
245 1 0 |a Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to RADICAL-INDUCED CELL DEATH1 
264 1 |c 2018 
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500 |a Citation Status MEDLINE 
520 |a © 2018 The Authors. New Phytologist © 2018 New Phytologist Trust. 
520 |a The oomycete pathogen Hyaloperonospora arabidopsidis (Hpa) causes downy mildew disease on Arabidopsis. To colonize its host, Hpa translocates effector proteins that suppress plant immunity into infected host cells. Here, we investigate the relevance of the interaction between one of these effectors, HaRxL106, and Arabidopsis RADICAL-INDUCED CELL DEATH1 (RCD1). We use pathogen infection assays as well as molecular and biochemical analyses to test the hypothesis that HaRxL106 manipulates RCD1 to attenuate transcriptional activation of defense genes. We report that HaRxL106 suppresses transcriptional activation of salicylic acid (SA)-induced defense genes and alters plant growth responses to light. HaRxL106-mediated suppression of immunity is abolished in RCD1 loss-of-function mutants. We report that RCD1-type proteins are phosphorylated, and we identified Mut9-like kinases (MLKs), which function as phosphoregulatory nodes at the level of photoreceptors, as RCD1-interacting proteins. An mlk1,3,4 triple mutant exhibits stronger SA-induced defense marker gene expression compared with wild-type plants, suggesting that MLKs also affect transcriptional regulation of SA signaling. Based on the combined evidence, we hypothesize that nuclear RCD1/MLK complexes act as signaling nodes that integrate information from environmental cues and pathogen sensors, and that the Arabidopsis downy mildew pathogen targets RCD1 to prevent activation of plant immunity 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Arabidopsis thaliana 
650 4 |a Hyaloperonospora arabidopsidis 
650 4 |a RADICAL-INDUCED CELL DEATH1 
650 4 |a oomycete pathogen 
650 4 |a pathogen effector 
650 4 |a plant innate immunity 
650 4 |a salicylic acid (SA) 
650 7 |a Arabidopsis Proteins  |2 NLM 
650 7 |a NPR1 protein, Arabidopsis  |2 NLM 
650 7 |a Nuclear Proteins  |2 NLM 
650 7 |a Proteins  |2 NLM 
650 7 |a RCD1 protein, Arabidopsis  |2 NLM 
650 7 |a ADP Ribose Transferases  |2 NLM 
650 7 |a EC 2.4.2.-  |2 NLM 
650 7 |a Salicylic Acid  |2 NLM 
650 7 |a O414PZ4LPZ  |2 NLM 
700 1 |a Asai, Shuta  |e verfasserin  |4 aut 
700 1 |a Rallapalli, Ghanasyam  |e verfasserin  |4 aut 
700 1 |a Sklenar, Jan  |e verfasserin  |4 aut 
700 1 |a Fabro, Georgina  |e verfasserin  |4 aut 
700 1 |a Kim, Dae Sung  |e verfasserin  |4 aut 
700 1 |a Lintermann, Ruth  |e verfasserin  |4 aut 
700 1 |a Jaspers, Pinja  |e verfasserin  |4 aut 
700 1 |a Wrzaczek, Michael  |e verfasserin  |4 aut 
700 1 |a Kangasjärvi, Jaakko  |e verfasserin  |4 aut 
700 1 |a MacLean, Daniel  |e verfasserin  |4 aut 
700 1 |a Menke, Frank L H  |e verfasserin  |4 aut 
700 1 |a Banfield, Mark J  |e verfasserin  |4 aut 
700 1 |a Jones, Jonathan D G  |e verfasserin  |4 aut 
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