Th1/17 cells, a subset of Th17 cells, are expanded in patients with active systemic lupus erythematosus
Copyright © 2018 Elsevier Inc. All rights reserved.
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 195(2018) vom: 15. Okt., Seite 101-106 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2018
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Interleukin-17 Interferon-gamma 82115-62-6 |
| Zusammenfassung: | Copyright © 2018 Elsevier Inc. All rights reserved. Skewed cytokine production characterizes T cells in Systemic Lupus Erythematosus (SLE). Among Th17 cells that are expanded in lupus, a subset (Th1/17) retains the ability to produce IFNγ. We aimed to analyze Th17 and Th1/17 cells in patients with SLE. Patients with active disease displayed increased percentages of circulating Τh17 and Th1/17 cells. Stimulated T cells from patients with lupus secreted significantly more IL-17 compared to healthy donors. Also, T cells from patients with active SLE released significantly lower levels of IFN-γ compared to controls. However, following stimulation, levels of IFN-γ also rose significantly. Our data suggest that lupus Th1/17 cells are not only expanded but also functional. In summary, in this study it was shown that patients with active SLE display increased Th17 and functional Th1/17 cells. This impaired T-cell axis might represent a possible future therapeutic target |
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| Beschreibung: | Date Completed 27.08.2019 Date Revised 27.08.2019 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2018.08.005 |