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cr uuu---uuuuu |
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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2018.08.001
|2 doi
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|a pubmed25n0957.xml
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|a (DE-627)NLM287382109
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|a (NLM)30099194
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|a (PII)S1521-6616(18)30473-X
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hoff, Sabine
|e verfasserin
|4 aut
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| 245 |
1 |
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|a MyD88 signaling in T regulatory cells by endogenous ligands dampens skin inflammation in filaggrin deficient mice
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 27.08.2019
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2018 Elsevier Inc. All rights reserved.
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|a Mutations in filaggrin are associated with atopic dermatitis. Filaggrin-deficient flaky tail (Flgft/ft) mice develop spontaneous inflammatory skin lesion that wax and wane. We show that loss of MyD88 promotes the persistence of skin lesions in Flgft/ft mice and exaggerates their expression of the Th17-associated cytokines Il7a and Il22. The development and persistence of skin lesions in Flgft/ft mice was independent of the microbiota. MyD88-mediated signals are shown to be important for the accumulation of T regulatory cells (Tregs) in lesional skin of Flgft/ft mice. Adoptive transfer of WT Tregs dampened the severity of skin lesions in MyD88-/-/Flgft/ft mice. These results suggest that MyD88 signaling in Treg cells by endogenous ligands attenuates skin inflammation in filaggrin deficiency
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a FLG protein, human
|2 NLM
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| 650 |
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|a Filaggrin Proteins
|2 NLM
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| 650 |
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|a Interleukin-17
|2 NLM
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| 650 |
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|a Interleukins
|2 NLM
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| 650 |
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|a Intermediate Filament Proteins
|2 NLM
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| 650 |
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|a Myeloid Differentiation Factor 88
|2 NLM
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| 700 |
1 |
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|a Oyoshi, Michiko K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hornick, Jason L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Geha, Raif S
|e verfasserin
|4 aut
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| 700 |
0 |
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|a NIH/NIAID funded Atopic Dermatitis Research Network
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 195(2018) vom: 30. Okt., Seite 88-92
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:195
|g year:2018
|g day:30
|g month:10
|g pages:88-92
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|u http://dx.doi.org/10.1016/j.clim.2018.08.001
|3 Volltext
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