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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.8b01569
|2 doi
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|a eng
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| 100 |
1 |
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|a De Vera, Jacqueline S
|e verfasserin
|4 aut
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| 245 |
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|a Self-Cleaning Interfaces of Polydimethylsiloxane Grafted with pH-Responsive Zwitterionic Copolymers
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Revised 20.11.2019
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Self-cleaning surfaces allow the reversible attachment and detachment of microorganisms which show great promise in regards to their reusability as smart biomaterials. However, a widely used biomaterial such as polydimethylsiloxane (PDMS) suffers from high biofouling activity and hydrophobic recovery that results in decreased efficiency and stability. A current challenge is to modify and fabricate self-cleaning PDMS surfaces by incorporating antifouling and pH-sensitive properties. To address this, we synthesized a zwitterionic and pH-sensitive random poly(glycidyl methacrylate- co-sulfobetaine methacrylate- co-2-(dimethylamino)ethyl methacrylate) polymer, poly(GMA- co-SBMA- co-DMAEMA). In this work, chemical modification of PDMS was done by grafting onto poly(GMA- co-SBMA- co-DMAEMA) after surface activation via UV and ozone for 90 min to ensure the formation of covalent bonds necessary for stable grafting. The PDMS grafted with G20-S40-D40 exhibit antifouling and pH-sensitive properties by mitigating fibrinogen adsorption, blood cell adhesion, and releasing 98% adhered E. coli bacteria after immersion at basic pH. The grafting of poly(GMA- co-SBMA- co-DMAEMA) presented in this work shows attractive potential for biomedical and industrial applications as a simple, smart, and effective method for the modification of PDMS interfaces
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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1 |
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|a Venault, Antoine
|e verfasserin
|4 aut
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| 700 |
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|a Chou, Ying-Nien
|e verfasserin
|4 aut
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|a Tayo, Lemmuel
|e verfasserin
|4 aut
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|a Chiang, Heng-Chieh
|e verfasserin
|4 aut
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|a Aimar, Pierre
|e verfasserin
|4 aut
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| 700 |
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|a Chang, Yung
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 35(2019), 5 vom: 05. Feb., Seite 1357-1368
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:35
|g year:2019
|g number:5
|g day:05
|g month:02
|g pages:1357-1368
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|u http://dx.doi.org/10.1021/acs.langmuir.8b01569
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