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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.8b01840
|2 doi
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|a pubmed24n0957.xml
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|a (DE-627)NLM287254941
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|a (NLM)30086233
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Tang, Zhonglan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Non-Cross-Linking Aggregation of DNA-Carrying Polymer Micelles Triggered by Duplex Formation
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 05.08.2019
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|a Date Revised 05.08.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Colloidal behaviors of particles functionalized with biomolecules are generally complicated. This study describes that colloidal behaviors of double-stranded (ds) DNA-carrying polymer micelles are well controlled by altering the molar ratio of single-stranded (ss) DNA moiety in the dsDNA shell. ssDNA-carrying micelles composed of a poly( N-isopropylacrylamide) (PNIPAAm) core surrounded by a dense shell of ssDNAs were prepared through self-assembly of PNIPAAm grafted with ssDNA by incubating its solution above the lower critical solution temperature. Spontaneous, non-cross-linking aggregation of the micelles was triggered by DNA duplex formation on the surface. Comparison of the critical coagulation concentration of NaCl among a series of the DNA-carrying micelles revealed the relationship between the helical structure of the surface-bound DNA and the colloidal stability of the micelles. The electrophoretic mobility analysis of the micelles indicated that the duplex formation reduced the structural flexibility of the surface-bound DNA, thereby decreasing the interparticle entropic repulsion. It is also suggested that the augmented rigidity of the surface-bound DNA increases the number of terminal base pairs facing the solvent, which could lead to multiple blunt-end stacking interaction among the micelles. Therefore, small DNA molecules could be considered unique surface-modifiers capable of controlling interactions between the surfaces of materials
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Acrylic Resins
|2 NLM
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|a Colloids
|2 NLM
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|a DNA, Single-Stranded
|2 NLM
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|a Micelles
|2 NLM
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|a poly-N-isopropylacrylamide
|2 NLM
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|a 25189-55-3
|2 NLM
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|a Sodium Chloride
|2 NLM
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|a 451W47IQ8X
|2 NLM
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| 700 |
1 |
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|a Takarada, Tohru
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maeda, Mizuo
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 34(2018), 49 vom: 11. Dez., Seite 14899-14910
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:34
|g year:2018
|g number:49
|g day:11
|g month:12
|g pages:14899-14910
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|u http://dx.doi.org/10.1021/acs.langmuir.8b01840
|3 Volltext
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